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Pathogenesis of Arterial Lesions Induced by Dopaminergic Compounds in the Rat 1
The induction of splanchnic arterial lesions in the rat by dopamine and FM is caused by stimulation of, and interaction between, alpha-adrenoceptors and dopaminergic DA1 receptors.
Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor selectivity.
The alpha-2/alpha-1 adrenoceptor selectivity ratio of SK&F 86466 is comparable to that obtained with agents such as yohimbine, making it a useful tool for characterization ofalpha-2 adrenoceptors and for investigation of their physiological role.
Pharmacological differentiation of postsynaptic alpha adrenoceptors in the dog saphenous vein.
Data indicate that the dog saphenous vein strip is a suitable in vitro preparation for study of drug action at both postsynaptic adrenoceptors inasmuch as either subpopulation of alpha adrenoceptor can be studied independently using specific agonists or antagonists.
Actions of iontophoretic phenytoin and medazepam on hippocampal neurons.
Phenytoin and MDZ differed with regard to the incidence of depression of spontaneous discharges, inhibition of slow firing cells, the proportion of granule cells depressed, and the duration of effect, which may be due to potency and pharmacokinetic factors or dissimilar mechanisms of action when the compounds are applied directly to single neurons.
Suppression of Pentylenetetrazol‐Elicited Seizure Activity by Intraosseous Propranolol in Pigs
The data demonstrate that propranolol possesses anticonvulsant activity against PTZ‐induced seizure in the pig, and the intraosseous route is a rapid and effective alternative venous access for proPRanolol administration in swine.
Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat.
SK&F 86466 was even less effective in the two-kidney one-clip Goldblatt model in which hypertension is maintained by the renin-angiotensin system rather than by the sympathetic nervous system, but was also an effective antihypertensive agent in the spontaneously hypertensive rat.