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Mechanisms of action and clinical characteristics of three atypical antidepressants: venlafaxine, nefazodone, bupropion.
Tricyclic antidepressants have multiple sites of pharmacological actions which are responsible for their tolerability and toxicological problems as well as their efficacy. That fact has prompted the… Expand
Specific high-affinity binding sites for [3H]Ro 5-4864 in rat brain and kidney.
- H. Schoemaker, R. Boles, W. D. Horst, H. Yamamura
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 April 1983
The binding of the novel ligand [3H]Ro 5-4864 to membrane preparations of rat kidney and brain was studied. [3H]Ro 5-4864 binds with high affinity (Kd = 0.6 nM) to a single saturable population of… Expand
N-isopropyl-[123I] p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain.
- H. S. Winchell, W. D. Horst, L. Braun, W. Oldendorf, R. Hattner, H. Parker
- Chemistry, Medicine
- Journal of nuclear medicine : official…
- 1 October 1980
The kinetics of N-isopropyl-p-[123I]iodoamphetamine in rat brains were determined by serial measurements of brain uptake index (BUI) after intracarotid injection; also studied were its effects on… Expand
Fluoxetine impairs clearance of alprazolam but not of clonazepam
- D. Greenblatt, S. Preskorn, M. Cotreau, W. D. Horst, J. Harmatz
- Clinical pharmacology and therapeutics
- 1 November 1992
Volunteer male subjects received single 1.0 mg oral doses of alprazolam and of clonazepam on two occasions, during coadministration of 40 mg/day fluoxetine or of placebo. When the sequence of trials… Expand
A pharmacokinetic/pharmacodynamic/receptor binding model to predict the onset and duration of pharmacological activity of the benzodiazepines
- M. Jack, W. Colburn, +4 authors R. O'brien
- Medicine, Chemistry
- Progress in Neuro-Psychopharmacology and…
- 31 December 1983
Ex vivo receptor binding as a function of time was determined in Charles River rats. The pharmacokinetic and protein binding parameters in man as well as the ex vivo receptor binding parameters in… Expand
Norepinephrine Metabolism in Hypertrophied Rat Hearts
EVIDENCE FOR A FALSE NEUROCHEMICAL TRANSMITTER AS A MECHANISM FOR THE HYPOTENSIVE EFFECT OF MONOAMINE OXIDASE INHIBITORS.
Catechol-O-methyl transferase in erythrocytes and fat cells.
Correlation of changes in the GABA-ergic system with the development of spasticity in paraplegic cats.
Following spinal cord transection there occurred decreases in Km and Vmax of glutamate decarboxylase (GAD) both above and below the lesion, and an initial decrease in the concentration of GABA.… Expand
Coadministration of nefazodone and desipramine: a pharmacokinetic interaction study.
OBJECTIVE To determine the potential for pharmacokinetic interaction between nefazodone (NFZ), and desipramine (DMI). METHOD A single center, open-label, multiple-dose, parallel-group… Expand