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Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions: an overview.
Spray-dried dispersions (SDDs) of low-solubility drugs have been prepared using the polymer hydroxypropyl methylcellulose acetate succinate (HPMCAS). For a variety of drug structures, these SDDsExpand
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  • 18
Drug polymorphism and dosage form design: a practical perspective.
Formulators are charged with the responsibility to formulate a product which is physically and chemically stable, manufacturable, and bioavailable. Most drugs exhibit structural polymorphism, and itExpand
  • 410
  • 8
The physical properties of glycolipids.
  • W. Curatolo
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 24 June 1987
  • 197
  • 5
Utility of Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) for Initiation and Maintenance of Drug Supersaturation in the GI Milieu
PurposeTo identify materials and processes which effect supersaturation of the GI milieu for low solubility drugs in order to increase oral bioavailability.MethodsA variety of small and polymericExpand
  • 211
  • 5
Physical chemical properties of oral drug candidates in the discovery and exploratory development settings
Abstract The advent of automated in vitro screening of hundreds of thousands of compounds has introduced biases into the drug discovery process that have significant implications for subsequent drugExpand
  • 184
  • 5
Intestinal Permeability Enhancement: Efficacy, Acute Local Toxicity, and Reversibility
The absorption of the polar drug phenol red was assessed in a rat intestinal perfusion model, in the presence of a variety of potential intestinal permeability enhancers. Both the absorption rateExpand
  • 211
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Computation of brain-blood partitioning of organic solutes via free energy calculations.
The ratio of brain-blood partitioning, log(Cbrain/Cblood) (log BB), of a series of compounds that range from simple solutes to histamine H2 antagonists was correlated with computed solvation freeExpand
  • 169
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Phase behavior and structural characteristics of hydrated bovine brain gangliosides.
Hydrated bovine brain gangliosides have been studied by differential scanning calorimetry, X-ray diffraction, and polarized light microscopy. Over the hydration range 18-50 wt.% H2O, mixed brainExpand
  • 64
  • 2
The interactions of 1-palmitoyl-2-oleylphosphatidylcholine and bovine brain cerebroside.
  • W. Curatolo
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 1986
Model membranes composed of 1-palmitoyl-2-oleylphosphatidylcholine (POPC) and bovine brain galactocerebroside (BOV-CER) have been studied by differential scanning calorimetry (DSC). POPC is aExpand
  • 43
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A calorimetry and deuterium NMR study of mixed model membranes of 1-palmitoyl-2-oleylphosphatidylcholine and saturated phosphatidylcholines.
Binary phase diagrams have been constructed from differential scanning calorimetry (DSC) data for the systems 1-palmitoyl-2-oleylphosphatidylcholine (POPC)/dimyristoylphosphatidylcholine (DMPC),Expand
  • 79
  • 2