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Management of acne: a report from a Global Alliance to Improve Outcomes in Acne.
Inducible erythromycin resistance in staphlyococci is encoded by a member of the ATP‐binding transport super‐gene family
- J. Ross, E. Eady, J. Cove, W. Cunliffe, S. Baumberg, J. Wootton
- Biology, MedicineMolecular microbiology
- 1 July 1990
The deduced sequence of the 488‐amino‐acid protein (MsrA) revealed the presence of two ATP‐binding motifs homologous to those of a family of transport‐related proteins from Gram‐negative bacteria and eukaryotic cells, including the P‐glycoprotein responsible for multidrug resistance.
Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses1
Data suggest that P. acnes triggers inflammatory cytokine responses in acne by activation of TLR2, which may provide a novel target for treatment of this common skin disease.
Post‐adolescent acne: a review of clinical features
Most patients had persistent acne; but true late‐onset acne (onset after the age of 25 years) was seen in 28 (18.4%) of women and four (8.3%) of men, and a family history revealed that 100 (50%) of patients had a first‐degree relative with post‐adolescent acne.
Inflammatory events are involved in acne lesion initiation.
- A. Jeremy, D. Holland, S. G. Roberts, K. Thomson, W. Cunliffe
- Biology, MedicineThe Journal of investigative dermatology
- 1 July 2003
Novel evidence is provided for vascular endothelial cell activation and involvement of inflammatory responses in the very earliest stages of acne lesion development.
Antibiotic‐resistant acne: lessons from Europe
This data indicates that despite numerous reports of skin colonization by antibiotic‐resistant propionibacteria among acne patients, accurate prevalence data are available only for the U.K.
Prevalence of facial acne in adults.
- V. Goulden, G. Stables, W. Cunliffe
- MedicineJournal of the American Academy of Dermatology
- 1 October 1999
This study shows a prevalence of clinical facial acne in women of 12%, which is likely to persist into middle age, similar to other studies on the prevalence of acne in the adult population.
16S rRNA Mutation Associated with Tetracycline Resistance in a Gram-Positive Bacterium
- J. Ross, E. Eady, J. Cove, W. Cunliffe
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 July 1998
Comparing the nucleotide sequences of the 16S rRNA genes from 16 susceptible and 21 resistant clinical isolates and 6 laboratory-selected tetracycline-resistant mutants of a susceptible strain concluded that E. coli strains carrying the mutant plasmid were more resistant to tetrACYcline than those carrying the wild-type plasmids both in MIC determinations and when grown in tetracellular liquid medium.
Scarred for life?
Acne vulgaris is a common inflammatory dermatosis capable of producing significant psychological and physical scarring. The following work describes the benefit of using a questionnaire as a clinical…
Evaluation of the modified Alvarado score in the diagnosis of acute appendicitis: a prospective study.
- M. Kalan, D. Talbot, W. Cunliffe, A. J. Rich
- MedicineAnnals of the Royal College of Surgeons of…
- 1 November 1994
The presence of a high Alvarado score was found to be an easy and satisfactory aid to early diagnosis of appendicitis in children and men, however, the false-positive rate for appendix in women was unacceptably high.