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Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density.
Low serum IGF-I levels found in men with IOM are associated with homozygosity for a specific allele of the insulin growth factor-I microsatellite (192/192), and individual variation in serum IGF -I levels is influenced by genetic factors and may be specifically influenced by variation at the IGF- I structural locus. Expand
Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data.
The dose response effect of smoking on serum cholesterol concentration suggests a gradient of increased absolute risk of coronary artery disease between light and heavy smokers. Expand
Reference distributions for the negative acute‐phase serum proteins, albumin, transferrin and transthyretin: A practical, simple and clinically relevant approach in a large cohort
Inflammation is associated with diverse clinical conditions accompanied by characteristic changes in serum levels of the acute‐phase proteins that can be used to stage the inflammatory process andExpand
Maternal obesity and markers of inflammation in pregnancy.
Maternal obesity in pregnancy is associated with changes in cytokines, protein hormones and acute phase proteins in the second trimester, with an increase in MCP-1 in the morbid obesity category, and a increase in Leptin and hsCRP with increasing BMI category. Expand
Genetic Variation in Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 (LOX1) Gene and the Risk of Coronary Artery Disease
Common genetic variation in the LOX1 gene may be associated with the risk of coronary artery disease in white women, and electrophoretic mobility shift assay data show that the 3′UTR polymorphic sequence affects the binding of a putative transcription factor in an allele-specific manner. Expand
Lipoprotein(a) as a risk factor for ischemic heart disease: metaanalysis of prospective studies.
Evidence is provided in support of a causal role for lipoprotein(a) in the development of atherosclerosis and the separation in values between cases and controls is not, however, sufficient to allow the use of Lp( a) as a screening test in the general population. Expand
Mid-gestational maternal free thyroxine concentration and offspring neurocognitive development at age two years.
Isolated hypothyroxinemia during the second trimester is not associated with significantly lower BSID-III scores at age 2 yr, compared with scores for offspring of matched euthyroxinemic women. Expand
Reference distributions for immunoglobulins A, G, and M: A practical, simple, and clinically relevant approach in a large cohort
Using automated immunoassay values from 115,017 serum samples from northern New England patients to provide more reliable and comprehensive reference distributions for IgA, IgG, and IgM measurements enables interpretation of serum immunoglobulin measurements using a common unit (multiples of the median) that is independent of age or gender. Expand
Background staining in immunoblot assays. Reduction of signal caused by cross-reactivity with blocking agents.
As the primary antibody in these immunoblot assays was human IgG, human serum albumin was investigated as a blocking agent; this approach eliminated the problem of blocking-specific background. Expand