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Immunohistochemical and ultrastructural studies on the exenterated orbital tissues of a patient with Graves' disease.
The exenterated orbital contents obtained post mortem from a 47-year-old man who had an eight-month history of treated hyperthyroidism and a two-month history of visual complaints were examined… Expand
Kinetics and components of the flash photocurrent of isolated retinal rods of the larval salamander, Ambystoma tigrinum.
1. Membrane currents initiated by intense, 20 microseconds flashes (photocurrents) were recorded from isolated salamander rods by combined extracellular suction electrodes and intracellular… Expand
On the asymmetry of frog retinal rod outer segment disk membranes.
- J. Corless, W. Cobbs, M. Costello, J. Robertson
- Chemistry, Medicine
- Experimental eye research
- 1 September 1976
Abstract Freeze-fracture studies on intact frog rod outer segments have been carried out using a device designed to minimize surface contamination and inadvertent specimen etching. When fractured and… Expand
Cyclic GMP increases photocurrent and light sensitivity of retinal cones
Like retinal rods, cone photoreceptors contain cyclic GMP and light-activated phosphodiesterase1–3. The cGMP phosphodiesterase cascade is thought to mediate phototransduction in rods. Biochemical… Expand
Definition of tolerance to continuous hyperoxia in man - An abstract report of Predictive Studies V
The overall goals, design, and procedures of Predictive Studies V are discussed as well as the specific elements of neural effects produced by prolonged hyperoxia. It is noted that Predictive Studies… Expand
Visual transduction in vertebrate rods and cones: A tale of two transmitters, calcium and cyclic GMP
La transduction visuelle englobe la succession des evenements declenches par l'absorption des photons entrainant la modulation locale du current de la membrane du segment externe. Le phenomene est… Expand
Follicle-stimulating hormone-secreting pituitary adenomas: correlation of reduction of adenoma size with reduction of hormonal hypersecretion after transsphenoidal surgery.
- R. Harris, N. Schatz, T. Gennarelli, P. Savino, W. Cobbs, P. Snyder
- The Journal of clinical endocrinology and…
- 1 June 1983
Ten men who had FSH-secreting pituitary adenomas were evaluated before and 4-6 weeks after transsphenoidal surgery to determine whether reduction of adenoma mass would ameliorate the hormonal… Expand
Cyclic GMP can increase rod outer-segment light-sensitive current 10-fold without delay of excitation
To test the hypothesis that cyclic GMP is the internal messenger coupling rhodopsin activation to membrane excitation in vertebrate rod photoreceptors, we used a novel technique combining measurement… Expand
Superior division paresis of the oculomotor nerve.
Five patients with isolated ptosis and a paresis of ocular elevation in abduction consistent with an isolated superior division III nerve palsy are reported. In all instances the III nerve appeared… Expand
Light and dark active phosphodiesterase regulation in salamander rods
- W. Cobbs
- Medicine, Chemistry
- The Journal of general physiology
- 1 September 1991
We studied the activation of 3',5'-cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE) by using a cell-permeant enzyme inhibitor. Rods of Ambystoma tigrinum held in a suction electrode were… Expand