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Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
Although epithelial ovarian cancers (EOCs) have been thought to arise from the simple epithelium lining the ovarian surface or inclusion cysts, the major subtypes of EOCs show morphologic features… Expand
Activated Signal Transducer and Activator of Transcription (STAT) 3
Constitutive activation of the Janus-activated kinase/signal transducer and activator of transcription (STAT) pathway promotes the proliferation and survival of cancer cells in culture and is… Expand
Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution.
Using the differential display method to analyze mRNA expression in hepatocellular carcinoma (HCC) and nontumor livers, we cloned a full-length cDNA of 2263 bp, which was designated GTR2-2 and was… Expand
Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: role in epithelial-mesenchymal transition.
- H. Yoshida, R. Broaddus, W. Cheng, Susu Xie, H. Naora
- Biology, Medicine
- Cancer research
- 15 January 2006
Homeobox genes encode transcription factors that control cell differentiation and play essential roles in developmental patterning. Increasing evidence indicates that many homeobox genes are… Expand
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.
- H. Yoshida, W. Cheng, +5 authors H. Naora
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 25 May 2004
Dissemination of ovarian cancer is a major clinical challenge and is poorly understood at the molecular level due to a lack of suitable experimental models. During normal development of the… Expand
Cancer stem cells, epithelial-mesenchymal transition, and drug resistance in high-grade ovarian serous carcinoma.
Although epithelial ovarian cancer cells are eliminated by debulking surgery and chemotherapy during initial treatment, it is believed that only a subset of cancer cells, that is, cancer stem cells,… Expand
Novel injectable calcium phosphate/chitosan composites for bone substitute materials.
- Hua Liu, H. Li, W. Cheng, Yuan Yang, M. Zhu, Changren Zhou
- Medicine, Materials Science
- Acta biomaterialia
- 1 September 2006
In this study, a novel injectable bone substitute material was developed which consists of chitosan, citric acid and glucose solution as the liquid phase, and tricalcium phosphate powder as the solid… Expand
Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet-rich plasma.
Injectable scaffolds held great promise for the reconstruction of bone defects. We prepared an injectable composite named PTC by combining TCP/chitosan (TC) with platelet-rich plasma (PRP). The… Expand
MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression.
- W. Tang, Y. Jiang, Xiao-Xin Mu, L. Xu, W. Cheng, X. Wang
- Biology, Medicine
- Cellular signalling
- 1 July 2014
The activation of homeobox A10 (HOXA10) has been proved to be an important event in epithelial ovarian carcinogenesis, yet its regulation in epithelial ovarian cancer (EOC) is still not fully… Expand
UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis
Urothelial cancer associated 1 (UCA1) is an example of functional long noncoding RNAs involved in many biologic processes. However, little is known about the association between UCA1 expression and… Expand