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Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.
A structural model is proposed in which FAD mutations (V44M and V44A) can open the T48 site γ-secretase for the initial ε-cleavage, and consequently shift cleavage preference towards Aβ42.
Structural and Mutational Studies of a Hyperthermophilic Intein from DNA Polymerase II of Pyrococcus abyssi*
NMR spin relaxation indicates that the Pab PolII intein is significantly more rigid than mesophilic inteins, which may contribute to the higher optimal temperature for protein splicing.
Intramolecular disulfide bond between catalytic cysteines in an intein precursor.
The presence of an intramolecular disulfide bond is reported, which may contribute to the redox control of splicing activity in hypoxia and at low temperature and point to the intriguing possibility that inteins may act as switches to control extein function.
Recombinant Protein Vaccines, a Proven Approach Against Coronavirus Pandemics
The current public information on the nature and on the development status of recombinant subunit antigens and adjuvants targeting SARS-CoV-2 infections is summarized.