Share This Author
Fmoc solid phase peptide synthesis : a practical approach
Introduction - a retrospective viewpoint White & Chan: Basic Principles Chan & White: Basic Procedures Albericio et al: Preparation and Handling of Peptides Containing Methionine and Cysteine Quibell…
Look who's talking: communication and quorum sensing in the bacterial world
- P. Williams, K. Winzer, W. Chan, M. Cámara
- BiologyPhilosophical Transactions of the Royal Society B…
- 29 July 2007
Quorum sensing enables a bacterial population to mount a co-operative response that improves access to nutrients or specific environmental niches, promotes collective defence against other competitor prokaryotes or eukaryotic defence mechanisms and facilitates survival through differentiation into morphological forms better able to combat environmental threats.
Structure, activity and evolution of the group I thiolactone peptide quorum‐sensing system of Staphylococcus aureus
The addition of exogenous synthetic AIPs to S. aureus inhibited the production of toxic shock syndrome toxin (TSST‐1) and enterotoxin C3, confirming the potential of quorum‐sensing blockade as a therapeutic strategy.
Differential recognition of Staphylococcus aureus quorum-sensing signals depends on both extracellular loops 1 and 2 of the transmembrane sensor AgrC.
Isolation and characterisation of two degradation products derived from the peptide antibiotic nisin
Structure‐activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin
Regulation of Neurotoxin Production and Sporulation by a Putative agrBD Signaling System in Proteolytic Clostridium botulinum
- C. Cooksley, I. Davis, K. Winzer, W. Chan, M. Peck, N. Minton
- BiologyApplied and Environmental Microbiology
- 7 May 2010
In comparison to the wild-type strains, these strains exhibited drastically reduced sporulation and, for C. botulinum, also reduced production of neurotoxin, suggesting that both phenotypes are controlled by quorum sensing.
Methicillin Resistance Reduces the Virulence of Healthcare-Associated Methicillin-Resistant Staphylococcus aureus by Interfering With the agr Quorum Sensing System
It is shown that resistance to methicillin induces changes in the cell wall, which affects the bacteria's agr quorum sensing system, which leads to reduced toxin expression and, as a consequence, reduced virulence in a murine model of sepsis.
A novel lysine-protecting procedure for continuous flow solid phase synthesis of branched peptides
A new amine protecting group which can be used orthogonally with both Fmoc and Boc protection is reported; by employing lysine protected appropriately as the branching motif, a 34 residue di-epitopic…