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Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro
The ethanolic extracts from five plants and one folklore recipe showed potent cytotoxic activity against CL-6 cell, and HepG2 appears to be the most resistant to the tested extracts. Expand
The identities and anti-herpes simplex virus activity of Clinacanthus nutans and Clinacanthus siamensis.
The combination of macroscopic, microscopic and biomolecular method are able to authenticate these closely related plants and both of them have a potency to be an anti-HSV agent. Expand
In vitro antimalarial interactions between mefloquine and cytochrome P450 inhibitors.
Analysis of isobologram revealed a trend of decreasing of fraction IC(50) (FIC), which indicates synergistics of the either quinidine or ketoconazole with mefloquine for both chloroquine-resistant and chloroquin-sensitive clones. Expand
Prevalence and distribution of glucose-6-phosphate dehydrogenase (G6PD) variants in Thai and Burmese populations in malaria endemic areas of Thailand
Investigation of the prevalence of G6PD variants in Thai population who resided in malaria endemic areas of Thailand as well as the Burmese population who residing in areas along the Thai-Myanmar border indicates difference in the prevalence and distribution of G 6PD gene variants among the Thai andBurmese populations in different malaria endemic Areas. Expand
Plasmodium vivax Drug Resistance Genes; Pvmdr1 and Pvcrt-o Polymorphisms in Relation to Chloroquine Sensitivity from a Malaria Endemic Area of Thailand
The results suggest that chloroquine resistance gene is now spreading in this area along the Thai-Myanmar border in Mae Sot district of Thailand, and monitoring ofchloroquine resistant molecular markers provide a useful tool for future control of P. vivax malaria. Expand
Genotyping of polymorphic marker (MSP3α and MSP3β) genes of Plasmodium vivax field isolates from malaria endemic of Thailand
Results strongly support that P. vivax isolates in Thailand are markedly diverse, and PCR/RFLP provides a powerful method for genotyping and identification of mixed parasite infections without requirement of gene sequencing. Expand
Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine
The ethanolic extracts from 19 medicinal plants/herbal formulation exhibited promising activity against both K1 and 3D7 clones of P. falciparum with survival of less than 50 % at the concentration of 50 μg/ml, and Benjakul Formulation 1 and Pra-Sa-Prao-Yhai Formulation showed potent antimalarial activity with median range IC50 values of more than 10 μG/ml. Expand
Antimalarial activity of plumbagin in vitro and in animal models
The in vitro and in vivo antimalarial activity of plumbagin including its acute and subacute toxicity in mice was evaluated and it was found that the dose of 25 mg/kg body weight given for 4 days was safe and produced weak antimalaria activity. Expand
Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate.
In vitro sensitivity results indicate the increase in susceptibility of P. falciparum strains in Thailand to CQ, while the susceptibility to MQ and QN was markedly declined, and the pattern of cross-resistance was observed between MQ vs QN vs AS. Expand
Cytotoxic activities and effects of atractylodin and β-eudesmol on the cell cycle arrest and apoptosis on cholangiocarcinoma cell line.
Cholangiocarcinoma (CCA) is the cancer of bile duct with high mortality rate particularly in Thailand. The clinical efficacy of the standard chemotherapeutics remains unsatisfactory, and therefore,Expand