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Biological characterization of the Amazon coral Micrurus spixii snake venom: Isolation of a new neurotoxic phospholipase A2.
Neuromuscular paralysis by the basic phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and…
Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals: radiochemical and real-time video-microscopy studies.
Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids
This work performed structural and functional studies with Piratoxin-I, a Lys49-PLA2 from Bothropspirajai venom, complexed with two compounds present in several plants used in folk medicine against snakebites and corroborate the previously proposed mechanism of action of PLA2s-like.
Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis.
Differential morphofunctional characteristics and gene expression in fast and slow muscle of rats with monocrotaline-induced heart failure
- Raquel Santilone Bertaglia, Joyce Reissler, M. D. Silva
- BiologyJournal of Molecular Histology
- 21 April 2011
Investigation of morphofunctional characteristics and gene expression in Soleus (SOL—oxidative and slow twitching muscle) and in Extensor Digitorum Longus (EDL—glycolytic and fast twitching Muscle) during HF indicates that monocrotaline induced HF promoted more prominent biochemical, morphological and functional changes in SOL.
Antagonism of myotoxic and paralyzing activities of bothropstoxin-I by suramin.
Understanding the in vitro neuromuscular activity of snake venom Lys49 phospholipase A2 homologues.
Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin.
- G. Salvador, T. Dreyer, M. Fontes
- Biology, ChemistryActa crystallographica. Section D, Biological…
- 1 October 2015
It is demonstrated for the first time that the inhibitor binds to the surface of the toxin, obstructing the sites involved in membrane docking and disruption according to the proposed myotoxic mechanism and higher-order oligomeric formation by interaction with interfacial suramins was observed, which may also aid the inhibitory process.
Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A₂-like.