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Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma
Gliomas are the most common and lethal primary tumors of the central nervous system (CNS). Despite current rigorous treatment protocols, effect of chemotherapy has failed to improve patient outcomeExpand
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Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice
Abstract14-3-3 protein has emerged as critical regulators of diverse cellular responses. Previous studies found that strong 14-3-3 protein expression was observed and associated with tumor genesisExpand
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Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds
BackgroundThe current study was to evaluate the anti-thrombotic effect of alpha-linolenic acid (ALA) which was isolated and purified from Jiaomu in vivo.MethodsThe seeds were crushed and subsequentlyExpand
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Isoform-specific expression of 14-3-3 proteins in human astrocytoma
BACKGROUND 14-3-3 protein plays crucial roles in tumorigenesis, including the maintenance of cell cycle and DNA repair, the prevention of apoptosis, among others. In mammalian cells, seven 14-3-3Expand
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A20 is overexpressed in glioma cells and may serve as a potential therapeutic target
Objective: A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells. This study investigates A20 expression in human glioma tissuesExpand
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Identification of 14-3-3 protein isoforms in human astrocytoma by immunohistochemistry
The 14-3-3 proteins are highly conserved, ubiquitous molecules involved in a variety of biologic events, such as cell cycle control, and apoptosis. In our previous study, it has been proved that theyExpand
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14-3-3Zeta Positive Expression is Associated With a Poor Prognosis in Patients With Glioblastoma
BACKGROUND:When identifying clinical markers predicting clinical outcome, disease recurrence and resistance to therapies often determine the diagnosis and therapy of some cancer types. OBJECTIVE:ToExpand
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Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells.
Akt is becoming an attractive target in the development of anti-tumor agents. In the present study, we aimed to discover novel negative Akt regulators against malignant glioma. An Akt regulatorExpand
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Deposition of Doxorubicin in Rats following Administration of Three Newly Synthesized Doxorubicin Conjugates
We previously reported the synthesis of three DOX conjugates that represented different targeting vehicles and showed them to have antitumor activity both in vitro and in vivo. However, theExpand
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[Alarming effect of intraoperative neuroelectrophysiological monitoring in microvascular decompression for primary trigeminal neuralgia].
OBJECTIVE To explore the alarming effect of intraoperative neuroelectrophysiological monitoring in microvascular decompression (MVD) for primary trigeminal neuralgia. METHODS In 2014, a total of 44Expand
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