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Activity and Regulation of the Centrosome-associated Proteasome*
TLDR
Evidence is provided that centrosomes contain the active 26 S proteasome that degrades ubiquitinated-protein and proteasomes-specific peptide substrates and highlights a novel function for this organizing structure. Expand
Regulation of Cl−/ HCO3 −Exchange by Cystic Fibrosis Transmembrane Conductance Regulator Expressed in NIH 3T3 and HEK 293 Cells*
TLDR
The novel finding of regulation of Cl−/H CO3 − exchange by CFTR reported here may have important physiological implications and explain, at least in part, the impaired HCO3 −secretion in CF. Expand
Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.
TLDR
It is reported that bardoxolone methyl (BARD) ameliorates ischemic murine AKI as assessed by both renal function and pathology, and it is suggested that BARD's effects on tubular and leukocyte HO-1 during isChemic AKI may be Nrf2 independent. Expand
Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme.
TLDR
Nine additional mutations in the 5alpha-reductase 2 gene in subjects with 5 alpha- reductase deficiency are described, providing insight into functional domains in the protein as well as an unusual acidic pH optimum characteristic of the 5Alpha-Reductase type 2 isozyme. Expand
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex*
TLDR
It is suggested that APH-1 plays a GXXXG-dependent scaffolding role in both the initial assembly and subsequent maturation and maintenance of the active γ-secretase complex. Expand
RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity
Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2Expand
Natural mutagenesis study of the human steroid 5α-reductase 2 isozyme
TLDR
Nine additional mutations in the 5alpha-reductase 2 gene in subjects with 5 alpha- reductase deficiency are described, providing insight into functional domains in the protein as well as an unusual acidic pH optimum characteristic of the 5Alpha-Reductase type 2 isozyme. Expand
Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein
TLDR
Structural complementation provides a means of monitoring protein solubility/misfolding in vivo, and should find utility in the screening for compounds that influence the pathological consequences of these processes. Expand
Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies.
TLDR
PA28 is established as a novel component of nuclear PML bodies, and it is suggested that PA28 may assemble or activate immunoproteasomes at this site as part of its role in proteasome-dependent MHC class I antigen presentation. Expand
Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.
TLDR
The present results are consistent with the overall published body of data obtained with triterpenoids and provide further evidence that these molecules are well tolerated without adverse effects on hepatobiliary or renal function in rodent models of diabetes and obesity. Expand
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