W. C. Ford

Publications51
h-index27
Citations2,362
Highly Influential Citations83
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  • Publications
  • Influence
Regulation of sperm function by reactive oxygen species.
  • W. C. Ford
  • Biology, Medicine
  • Human reproduction update
  • 1 September 2004
Sperm capacitation can be increased by the addition of reactive oxygen species (ROS) and decreased by antioxidants. Broadly consistent results have been achieved with a wide variety of methods and… Expand
  • 238
  • 11
The role of glucose in supporting motility and capacitation in human spermatozoa.
Glucose has been reported to be beneficial to human sperm for optimal capacitation and fertilization, although it is unclear whether glucose is required for providing extra metabolic energy through… Expand
  • 211
  • 8
Glycolysis and sperm motility: does a spoonful of sugar help the flagellum go round?
  • W. C. Ford
  • Biology, Medicine
  • Human reproduction update
  • 1 May 2006
It is doubtful that diffusion can deliver sufficient ATP from the mitochondria to sustain activity at the distal end of the sperm flagellum. Glycolytic enzymes bound to the fibrous sheath could… Expand
  • 204
  • 7
  • PDF
Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study…
The impact of male age on fecundity remains controversial. Here, a large population study was used to investigate the effect of paternal age on time to conception. All couples in the Avon Health… Expand
  • 216
  • 5
  • PDF
The indirect immunobead test for seminal antisperm antibodies and fertilization rates at in-vitro fertilization.
A series of 183 patients with positive indirect immunobead tests on semen was studied to determine the correlation in semen between specific antibody types, binding sites, antibody concentration, and… Expand
  • 53
  • 5
Intracellular calcium measurements in individual human sperm demonstrate that the majority can respond to progesterone.
OBJECTIVE To determine if human spermatozoa could be immobilized and intracellular calcium measurements made on individual cells to measure what proportion can respond to P. DESIGN Spermatozoa were… Expand
  • 42
  • 4
Effects of Ca-ATPase inhibitors on the intracellular calcium activity and motility of human spermatozoa.
Although evidence suggests that high intracellular calcium activity ([Ca2+]i) inhibits sperm motility, data concerning [Ca2+]i within, or slightly above, the physiological range are sparse,… Expand
  • 33
  • 4
The role of oxidative phosphorylation in the generation of ATP in human spermatozoa.
Washed human spermatozoa had an endogenous oxygen uptake of 2.14 +/- 0.17 nmol O2/10(8) spermatozoa/min (mean +/- s.e..m., n = 35) which was stimulated by succinate (Vmax = 9.64 +/- 0.44 nmol… Expand
  • 66
  • 3
  • PDF
A critical investigation of NADPH oxidase activity in human spermatozoa.
It has been suggested that human spermatozoa contain an NADPH oxidase that could generate reactive oxygen species involved in signalling pathways to promote fertility. The proposal depends on… Expand
  • 70
  • 3
  • PDF
Relative contribution of leukocytes and of spermatozoa to reactive oxygen species production in human sperm suspensions.
The contribution of leukocytes and of spermatozoa to reactive oxygen species (ROS) production in prepared sperm suspensions from donors and subfertility patients was compared. In both groups, more… Expand
  • 100
  • 3