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Angiogenesis in the human corpus luteum: simulated early pregnancy by HCG treatment is associated with both angiogenesis and vessel stabilization.
Luteal rescue with HCG is associated with a second wave of angiogenesis and vascular stabilization, and by the mid-luteal phase a mature vasculature was apparent, as shown by maximal endothelial cell and pericyte areas.
Localization and quantification of cyclic changes in the expression of endocrine gland vascular endothelial growth factor in the human corpus luteum.
It is established that in the human corpus luteum EG-VEGF is principally derived from granulosa lutein cells and that its synthesis is highest during the mid- to late luteal phase.
Measurement of circulating inhibin forms during the establishment of pregnancy.
- P. Illingworth, N. Groome, A. Mcneilly
- Biology, MedicineThe Journal of clinical endocrinology and…
- 1 April 1996
Data support the concept of different physiological roles for different inhibin forms in very early pregnancy, after stimulation of the corpus luteum by exogenous hCG, and in abnormal and failing human pregnancy.
The effect of luteal "rescue" on the expression and localization of matrix metalloproteinases and their tissue inhibitors in the human corpus luteum.
- W. C. Duncan, A. Mcneilly, P. Illingworth
- BiologyThe Journal of clinical endocrinology and…
- 1 July 1998
During maternal recognition of pregnancy, hCG prevents the normal increase in MMP-2 in the late luteal phase, which can function in an environment containing large amounts of TIMP-1, as they have a different cellular localization.
The In Utero Programming Effect of Increased Maternal Androgens and a Direct Fetal Intervention on Liver and Metabolic Function in Adult Sheep
Adult liver metabolism and signaling can be altered by early exposure to sex steroids implicating epigenetic regulation of metabolic disturbances that are common in PCOS.
The role of TGF-&bgr; in the pathophysiology of peritoneal endometriosis
- V. J. Young, S. F. Ahmad, W. C. Duncan, A. Horne
- Medicine, BiologyHuman reproduction update
- 1 September 2017
Together these studies suggest that TGF-β1 plays a major role in the development of peritoneal endometriosis lesions and that targeting this pathway may be of therapeutic potential.
Prenatal androgen exposure leads to alterations in gene and protein expression in the ovine fetal ovary.
Prenatal androgenization has direct actions on the fetal ovary, and these may contribute to the adult ovarian phenotype in the ovine model of polycystic ovary syndrome, and there are functional changes that may impact on ovarian development.
The SLIT-ROBO pathway: a regulator of cell function with implications for the reproductive system.
The roles this pathway could have in the development, physiology and pathology of the reproductive system are examined and areas for future research are highlighted that could further dissect the influence of the SLIT/ROBO pathway in reproduction.
Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1alpha in the follicle and corpus luteum.
Results indicate that HIF-1alpha is up-regulated after vascular inhibition, using VEGF Trap, in the follicle and corpus luteum, however, it is also acutely up- regulated during ovulation, which suggests a role for Hif-1 alpha in both hypoxic and hormonal regulation of ovarian V EGF expression in vivo.
Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome.
- K. Hogg, Julia M. Young, E. M. Oliver, C. Souza, A. Mcneilly, W. C. Duncan
- Biology, MedicineEndocrinology
In vitro the thecal cells of follicles secreted more LH-stimulated androstenedione after prenatal androgenization, suggesting a thecal defect induced during fetal life, the first evidence of increased thecal androgenic capacity in the absence of a PCOS phenotype.