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Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK
DnaK and other members of the 70-kilodalton heat-shock protein (hsp70) family promote protein folding, interaction, and translocation, both constitutively and in response to stress, by binding to… Expand
Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ.
- W. C. Suh, W. Burkholder, C. Lu, X. Zhao, M. Gottesman, C. Gross
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 22 December 1998
Chaperones of the Hsp70 family bind to unfolded or partially folded polypeptides to facilitate many cellular processes. ATP hydrolysis and substrate binding, the two key molecular activities of this… Expand
Replication Initiation Proteins Regulate a Developmental Checkpoint in Bacillus subtilis
We identified a signaling pathway that prevents initiation of sporulation in Bacillus subtilis when replication initiation is impaired. We isolated mutations that allow a replication initiation… Expand
Specificity of DnaK-peptide binding.
- A. Gragerov, L. Zeng, X. Zhao, W. Burkholder, M. Gottesman
- Biology, Medicine
- Journal of molecular biology
- 20 January 1994
The sequence specificity of DnaK substrate binding has been studied using a peptide display library. Based on the amino acid patterns that appeared in this selection, short peptides were synthesized… Expand
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
The phosphorylated form of the response regulator Spo0A (Spo0A~P) is required for the initiation of sporulation in Bacillus subtilis. Phosphate is transferred to Spo0A from at least four histidine… Expand
Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis.
- S. Rowland, W. Burkholder, Katherine A. Cunningham, M. Maciejewski, A. Grossman, G. King
- Biology, Medicine
- Molecular cell
- 5 March 2004
Histidine kinases are used extensively in prokaryotes to monitor and respond to changes in cellular and environmental conditions. In Bacillus subtilis, sporulation-specific gene expression is… Expand
YneA, an SOS-induced inhibitor of cell division in Bacillus subtilis, is regulated posttranslationally and requires the transmembrane region for activity.
Cell viability depends on the stable transmission of genetic information to each successive generation. Therefore, in the event of intrinsic or extrinsic DNA damage, it is important that cell… Expand
The Bacillus subtilis SftA (YtpS) and SpoIIIE DNA translocases play distinct roles in growing cells to ensure faithful chromosome partitioning
In several bacterial species, the faithful completion of chromosome partitioning is known to be promoted by a conserved family of DNA translocases that includes Escherichia coli FtsK and Bacillus… Expand
Changes in DnaA-dependent gene expression contribute to the transcriptional and developmental response of Bacillus subtilis to manganese limitation in Luria-Bertani medium.
The SOS response to DNA damage in bacteria is a well-known component of the complex transcriptional responses to genotoxic environmental stresses such as exposure to reactive oxygen species,… Expand
The histidine kinase inhibitor Sda binds near the site of autophosphorylation and may sterically hinder autophosphorylation and phosphotransfer to Spo0F
Histidine kinases are widely used by bacteria, fungi and plants to sense and respond to changing environmental conditions. Signals in addition to those directly sensed by the kinase are often… Expand