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Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
This work reorganized probes on more than a dozen popular GeneChips into gene-, transcript- and exon-specific probe sets in light of up-to-date genome, cDNA/EST clustering and single nucleotide polymorphism information, and demonstrates that the original Affymetrix probe set definitions are inaccurate. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
P50 sensory gating ratios in schizophrenics and controls: A review and data analysis
Standards of P50 collection and measurement would help determine whether the gating ratio can be sufficiently reliable to be labeled an endophenotype, and suggestions are made toward this goal. Expand
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
The astroglial distribution of the two glutamate transporters and l-glutamate-ammonia ligase strongly links glia to the pathophysiology of depression and challenges the conventional notion that depression is solely a neuronal disorder. Expand
A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands.
In a family study of 1,254 adult relatives of patients and controls, lifetime prevalences of major affective disorder (including schizoaffective) were 37%, 24%, 25%, 20% and 7% in relatives ofExpand
The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis.
  • J. Wu, W. Bunney
  • Psychology, Medicine
  • The American journal of psychiatry
  • 1990
The authors suggest that these phenomenological observations concerning relapse with a night of sleep or with naps after successful sleep deprivation would be compatible with the existence of a sleep-associated depressogenic process. Expand
Dysregulation of the fibroblast growth factor system in major depression.
Findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD) are described and all of the other growth factors and growth factor receptors detected in these postmortem samples are made available. Expand
Aggression, suicide, and serotonin: relationships to CSF amine metabolites.
The life history of aggression and history of suicidal behavior in 12 subjects with borderline personality disorders without major affective disorder were examined, and Histories of aggressive behaviors and of suicide attempts were significantly associated with each other. Expand
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
Analysis of additional samples will be required to confirm that variant(s) in these regions influence BP risk, and these chromosomal regions harbor genes implicated in cell cycle, neurogenesis, neuroplasticity, and neurosignaling. Expand
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
The largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4, achieves genome- wide significance including 18 novel loci, which provide potential new biological mechanisms for bipolar disorder. Expand