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Transcriptional profiling of intrinsic PNS factors in the postnatal mouse
TLDR
Real-time PCR and immunohistochemical studies confirmed that one representative TF, STAT3, is intrinsic to PNS neurons, and that constitutively active STAT3 is sufficient to promote CGN neurite outgrowth. Expand
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
TLDR
Comparing antibody-mediated mutations with sequence variation in circulating SARS-CoV-2 revealed substitutions that may attenuate neutralizing immune responses in some humans and thus warrant further investigation. Expand
Zinc in innate and adaptive tumor immunity
TLDR
Based on this novel synthesis, approaches which locally regulate zinc levels to promote survival of immune cells and/or induce tumor apoptosis are in order. Expand
Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
TLDR
Comparing the antibody-mediated mutational landscape in S with sequence variation in circulating SARS-CoV-2, it is defined substitutions that may attenuate neutralizing immune responses in some humans. Expand
Acoustic response properties of lagenar nerve fibers in the sleeper goby, Dormitator latifrons
TLDR
The lagena of D. latifrons plays a role in sound localization in elevation, particularly at high stimulus intensities where responses of most saccular fibers are saturated. Expand
Coding of acoustic particle motion by utricular fibers in the sleeper goby, Dormitator latifrons
TLDR
Results of this study indicate that the utricle in this vertebrate plays an auditory role in azimuth and that utricular fibers extend the response dynamic range of this species in directional hearing. Expand
Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands
TLDR
DC-derived exosomes (DCex) express on their surface TNF, FasL and TRAIL, by which they can trigger caspase activation and apoptosis in tumor cells, and this data demonstrate that DCex can mediate essential innate immune functions that were previously ascribed to DCs. Expand
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression.
TLDR
The combination of IL-2 with chloroquine increased long-term survival, decreased toxicity associated with vascular leakage, and enhanced immune cell proliferation and infiltration in the liver and spleen and provides a novel clinical strategy to enhance the efficacy of HDIL-2 immunotherapy for patients with cancer. Expand
p53/HMGB1 complexes regulate autophagy and apoptosis.
TLDR
A novel link between HMGB1 and p53 in the cross-regulation of apoptosis and autophagy in the setting of cell stress is provided, providing insights into their reciprocal roles in carcinogenesis. Expand
Rapid and extraction-free detection of SARS-CoV-2 from saliva by colorimetric reverse-transcription loop-mediated isothermal amplification
TLDR
Rapid and extraction-free detection of SARS-CoV-2 from saliva by colorimetric RT-LAMP is a simple, sensitive, and cost-effective approach with broad potential to expand diagnostic testing for the virus causing COVID-19. Expand
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