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Evoked mechanical responses of isolated cochlear outer hair cells.
Intracellular current administration evokes rapid, graded, and bidirectional mechanical responses of isolated outer hair cells from the mammalian inner ear. The cells become shorter in response to… Expand
Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems.
BETA2/NeuroD1 is a bHLH transcription factor that is expressed during development in the mammalian pancreas and in many locations in the central and peripheral nervous systems. During inner ear… Expand
Recordings from cat trapezoid body and HRP labeling of globular bushy cell axons.
1. Recordings were made from single nerve fibers in barbiturate-anesthetized cats in the midline trapezoid body, a location that permits selective sampling of efferent cells of the ventral cochlear… Expand
Responses to tones and noise of single cells in dorsal cochlear nucleus of unanesthetized cats.
1. Single-unit responses in the dorsal cochlear nucleus of unanesthetized, decerebrate cats have been divided into two categoreis. These have been differentiated on the basis of responses to… Expand
Outer Hair Cell Electromotility and Otoacoustic Emissions
- W. Brownell
- Medicine, Psychology
- Ear and hearing
- 1 April 1990
Outer hair cell electromotility is a rapid, force generating, length change in response to electrical stimulation. DC electrical pulses either elongate or shorten the cell and sinusoidal electrical… Expand
Micro- and nanomechanics of the cochlear outer hair cell.
- W. Brownell, A. Spector, R. Raphael, A. Popel
- Biology, Medicine
- Annual review of biomedical engineering
Outer hair cell electromotility is crucial for the amplification, sharp frequency selectivity, and nonlinearities of the mammalian cochlea. Current modeling efforts based on morphological,… Expand
Electrokinetic shape changes of cochlear outer hair cells
Rapid mechanical changes have been associated with electrical activity in a variety of non-muscle excitable cells1–5. Recently, mechanical changes have been reported in cochlear hair cells6–8. Here… Expand
The remarkable cochlear amplifier
This composite article is intended to give the experts in the field of cochlear mechanics an opportunity to voice their personal opinion on the one mechanism they believe dominates cochlear… Expand
Microscopic observation of cochlear hair cell motility.
- W. Brownell
- Chemistry, Medicine
- Scanning electron microscopy
Inner and outer hair cells were dissociated from mammalian organ of Corti and maintained using cell culture techniques. Micro-video recording was used to study motile responses in outer hair cells… Expand
Fine structure of the intracochlear potential field. I. The silent current.
Field potentials were recorded along radial tracks in scala tympani and scala vestibuli of the guinea-pig cochlea. A current density analysis revealed standing current density profiles that were… Expand