W. Brieher

Publications51
h-index23
Citations3,834
Highly Influential Citations176
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Molecular and functional analysis of cadherin-based adherens junctions.
Adherens junctions are specialized forms of cadherin-based adhesive contacts important for tissue organization in developing and adult organisms. Cadherins form protein complexes with cytoplasmic… Expand
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A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization.
We have previously characterized a non-O1, non-O139 Vibrio cholerae strain, AM-19226, that lacks the known virulence factors but contains components of a type III secretion system (T3SS). In this… Expand
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Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function
BACKGROUND Classical cadherin-based cellular adhesion is mediated by a multicomponent protein complex that links the adhesive binding activity of the cadherin ectodomain to the actin cytoskeleton.… Expand
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A quantitative analysis of contractility in active cytoskeletal protein networks.
Cells actively produce contractile forces for a variety of processes including cytokinesis and motility. Contractility is known to rely on myosin II motors which convert chemical energy from ATP… Expand
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α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction
α-Actinin-4 plays an important role in coupling actin nucleation to assembly at cadherin-based cell–cell adhesive contacts.
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Rapid actin monomer–insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1
Actin filaments in cells depolymerize rapidly despite the presence of high concentrations of polymerizable G actin. Cofilin is recognized as a key regulator that promotes actin depolymerization. In… Expand
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Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers
Turnover of actin filaments in cells requires rapid actin disassembly in a cytoplasmic environment that thermodynamically favors assembly because of high concentrations of polymerizable monomers. We… Expand
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Lateral dimerization is required for the homophilic binding activity of C-cadherin
Regulation of cadherin-mediated adhesion can occur rapidly at the cell surface. To understand the mechanism underlying cadherin regulation, it is essential to elucidate the homophilic binding… Expand
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Caspase-11 regulates cell migration by promoting Aip1–Cofilin-mediated actin depolymerization
Coordinated regulation of cell migration, cytokine maturation and apoptosis is critical in inflammatory responses. Caspases, a family of cysteine proteases, are known to regulate cytokine maturation… Expand
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Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps
Treatment of Xenopus animal pole tissue with activin results in the induction of mesodermal cell types and a dramatic elongation of the tissue. The morphogenetic movements involved in the elongation… Expand
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