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Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.
Differences in the pharmacokinetics of isoflavone glycosides compared with their respective beta-glycosides are demonstrated and indicate a need for improvement in quality assurance and standardization of such products.
Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability.
- K. Setchell, N. Brown, J. Heubi
- Chemistry, BiologyThe American journal of clinical nutrition
- 1 August 2002
Isoflavone glycosides are not absorbed intact across the enterocyte of healthy adults, and their bioavailability requires initial hydrolysis of the sugar moiety by intestinal beta-glucosidases for uptake to the peripheral circulation.
Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women.
- K. Setchell, M. Faughnan, A. Cassidy
- MedicineThe American journal of clinical nutrition
- 1 February 2003
The serum pharmacokinetics of (13)C isotopic forms of daidzein andgenistein were reproducible among healthy women, and genistein was more bioavailable than was daidzesin, suggesting that uptake is rate-limiting and saturable.
Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene.
- L. Lash, D. Putt, W. Brashear, R. Abbas, J. Parker, J. Fisher
- Biology, MedicineJournal of toxicology and environmental health…
- 8 January 1999
Direct, in vivo evidence of GSH conjugation of Tri in humans exposed to Tri is provided and markedly higher amounts of DCVG formation in males are demonstrated, suggesting that their potential risk to Tri-induced renal toxicity may be greater than that of females.
Conversion of trichloroacetic acid to dichloroacetic acid in biological samples.
- M. Ketcha, D. Stevens, D. A. Warren, C. Bishop, W. Brashear
- Chemistry, BiologyJournal of analytical toxicology
- 1 July 1996
Results reported here show that reduced hemoglobin may be involved in the acid-catalyzed conversion of TCA to DCA, and methods for esterifying TCA and DCA were developed, which are important for conducting pharmacokinetic studies.
The effect of smoking on placental and fetal zinc status.
Hemoglobins dioxygenate nitric oxide with high fidelity.
A species comparison of chloral hydrate metabolism in blood and liver.
- J. Lipscomb, D. Mahle, W. Brashear, C. Garrett
- BiologyBiochemical and biophysical research…
- 14 October 1996
TCOH is supported as the first major metabolite of TRI and CH in vivo, and the K(m) for hepatic TCOH formation is at least ten-fold lower than for TCA formation in these species.
Maternal and neonatal urinary excretion of sulfate and glucuronide ritodrine conjugates
- W. Brashear, B. R. Kuhnert, R. Wei
- Biology, ChemistryClinical pharmacology and therapeutics
- 1 December 1988
This study indicates that both the mother and neonate excrete glucuronide and sulfate conjugates of ritodrine, and significantly different metabolic profiles suggest that the neonate may be capable of forming conjugated metabolites of r itodrine.
N-Methyl-N'-Nitroguanidine: Irritation, Sensitization, and Acute Oral Toxicity, Genotoxicity, and Methods for Analysis in Biological Samples
The results of three genetic tests indicated that MNG does not interact with genetic material, and gastric contents and feces from treated animals showed no evidence of conversion of MNG to MNNG, which is a toxicological concern.