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A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin
TLDR
It is demonstrated that the AFB5-Aux/IAA co-receptor selectively binds the auxinic herbicide picloram, which broadens the effective concentration range of the hormone and may contribute to the complexity of auxin response.
UBIAD1 Mutation Alters a Mitochondrial Prenyltransferase to Cause Schnyder Corneal Dystrophy
TLDR
Accumulating evidence from the SCD familial mutation spectrum, protein homology across species, and molecular modeling suggest that protein function is likely down-regulated by SCD mutations.
Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity.
TLDR
Results indicate that Tyr67 and Leu205 play a key role in the binding of proline residues in the S2 pocket of cathepsin K and are required for its unique collagenase activity.
Functional characterization of a novel benzylisoquinoline O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L).
The benzylisoquinoline alkaloids are a highly diverse group of about 2500 compounds which accumulate in a species-specific manner. Despite the numerous compounds which could be identified, the
Post-translational modifications of the insect sulfakinins: sulfation, pyroglutamate-formation and O-methylation of glutamic acid.
TLDR
The two major forms of sulfakinins were identified and chemically characterized from an extract of 800 corpora cardiaca/corpora allata complexes of the American cockroach, Periplaneta americana and were shown to be highly active on both the heart and hindgut.
Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway
TLDR
It is reported that the product length synthesized by a single scIDS shifts depending on the divalent metal cofactor present, and the participation of this enzyme in the de novo synthesis of defensive monoterpenoids in the beetle larvae was revealed.
Selenium in chemistry and biochemistry in comparison to sulfur
TLDR
This review compiles and compares physicochemical properties of selenium and sulfur, synthetic routes to selenocysteine (Sec) and its peptides, and comparative studies of relevant thiols and selenols and their (mixed) dichalcogens, required to understand the special role ofSelenium in selenoproteins on the atomic molecular level.
Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study
TLDR
The higher clinical remission rate with tralokinumab than placebo suggests that tralokersumab may benefit some patients with UC, and the acceptable safety profile of tralokerumab was well tolerated.
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