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Structural definition of the C5a C terminus by two‐dimensional nuclear magnetic resonance spectroscopy
Correlation of the C5a tertiary structure with mutational analyses clarifies the significance of the functional and binding properties of Arg 62 and suggests that bothArg 62 and Arg 74 interact at the same binding site on the receptor.
Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist.
Characterization of human PLD2 and the analysis of PLD isoform splice variants
- P. Steed, K. Clark, W. Boyar, D. Lasala
- BiologyFASEB journal : official publication of the…
- 1 October 1998
The presence of Pleckstrin homology domains in the PLDs resolves several contradictory observations regarding PLD regulation and the domain structure of the proteins.
Optimization of halopemide for phospholipase D2 inhibition.
Residues 21–30 within the Extracellular N-terminal Region of the C5a Receptor Represent a Binding Domain for the C5a Anaphylatoxin*
- Zhigang Chen, Xiaolun Zhang, N. Gonnella, T. Pellas, W. Boyar, F. Ni
- Biology, ChemistryThe Journal of Biological Chemistry
- 24 April 1998
Binding induced resonance perturbations in the NMR spectra of the receptor fragments and the C5a molecules indicated that the isolated Nterminal domain or residues 1–34 of the C 5a receptor retain specific binding to C5o and to a C5e analog devoid of the agonistic C-terminal tail in the intact C5A.
Discriminatory roles for D1 and D2 dopamine receptor subtypes in the in vivo control of neostriatal cyclic GMP.
Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.
The results suggest that the same PGHS-2 tyrosyl radical serves as the oxidant for both cyclooxygenase and lipoxygen enzyme catalysis and that acetylation of PGHS -2 by ASA favors arachidonate binding in an altered conformation which results in abstraction of the pro-R hydrogen from C13 and formation of 11- and 15(R)-HETE.
Modulation of In Vivo Dopamine Release by D2 but Not D1 Receptor Agonists and Antagonists
The in vivo release of DA from mesolimbic and neostriatal DA neurons appears to be modulated by D2 but not by D1 receptors, whereas both receptor types can modulate DA metabolism.
The pharmacophore of the human C5a anaphylatoxin
- M. Toth, L. Huwyler, N. Galakatos
- Biology, ChemistryProtein science : a publication of the Protein…
- 1 August 1994
Ten noncontiguous amino acids from the structurally well‐defined 4‐helix core domain and the C‐terminal arginine‐containing tripeptide were found to contribute to the pharmacophore of human C5a.
Structure of human desArg-C5a.
- W. Cook, N. Galakatos, W. Boyar, R. Walter, S. Ealick
- ChemistryActa crystallographica. Section D, Biological…
- 1 February 2010
The crystal structure of human desArg-C5a has now been determined in two crystal forms and surprisingly, the protein crystallizes as a dimer and each monomer in the dimer has a three-helix core instead of the four-helIX bundle noted in the NMR structure determinations.