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Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Metal ions are essential cofactors for a wealth of biological processes, including oxidative phosphorylation, gene regulation and free-radical homeostasis. Failure to maintain appropriate levels of… Expand
Medical physiology : a cellular and molecular approach
Expression cloning of a mammalian proton-coupled oligopeptide transporter
IN mammals, active transport of organic solutes across plasma membranes was thought to be primarily driven by the Na+ gradient1–3. Here we report the cloning and functional characterization of a… Expand
The SLC4 family of HCO3− transporters
The SLC4 family consists of ten genes. All appear to encode integral membrane proteins with very similar hydropathy plots—consistent with the presence of 10–14 transmembrane segments. At least eight… Expand
Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors
The intracellular pH (pHi) of squid giant axons has been measured using glass pH microelectrodes. Resting pHi in artificial seawater (ASW) (pH 7.6-7.8) at 23 degrees C was 7.32 +/- 0.02 (7.28 if… Expand
The SLC4 family of HCO 3 - transporters.
The SLC4 family consists of ten genes. All appear to encode integral membrane proteins with very similar hydropathy plots-consistent with the presence of 10-14 transmembrane segments. At least eight… Expand
Regulation of intracellular pH.
- W. Boron
- Chemistry, Medicine
- Advances in physiology education
- 1 December 2004
The approach that most animal cells employ to regulate intracellular pH (pH(i)) is not too different conceptually from the way a sophisticated system might regulate the temperature of a house. Just… Expand
pH regulation in single glomerular mesangial cells. I. Acid extrusion in absence and presence of HCO3-.
- G. Boyarsky, M. Ganz, R. Sterzel, W. Boron
- Chemistry, Medicine
- The American journal of physiology
- 1 December 1988
We have developed a technique to measure the fluorescence of a pH-sensitive dye (2,7-biscarboxyethyl-5(6)-carboxyfluorescein) in single glomerular mesangial cells in culture. The intracellular… Expand
The SLC4 family of bicarbonate (HCO₃⁻) transporters.
- M. Romero, A. Chen, M. D. Parker, W. Boron
- Biology, Medicine
- Molecular aspects of medicine
- 1 April 2013
The SLC4 family consists of 10 genes (SLC4A1-5; SLC4A7-11). All encode integral membrane proteins with very similar hydropathy plots-consistent with 10-14 transmembrane segments. Nine SLC4 members… Expand