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10th Summit Meeting consensus: recommendations for regulatory approval for hormonal male contraception.
10th Summit Meeting consensus : recommendations for regulatory approval for hormonal male contraception.
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Effect of ornidazole on fertility of male rats: inhibition of a glycolysis-related motility pattern and zona binding required for fertilization in vitro.
The effects of the male antifertility agent ornidazole on glycolysis as a prerequisite for fertilization were investigated in rats. Antifertility doses of ornidazole inhibited glycolysis withinExpand
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Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro.
Nonhormonal contraceptives that act by blocking energy metabolism within sperm have the advantage over spermatogenic inhibitors by their fast onset of infertility and their almost immediateExpand
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Toxicity of ornidazole and its analogues to rat spermatozoa as reflected in motility parameters.
Ornidazole, a 5-nitro-imidazole derivative, has contraceptive properties in rats. As some ornidazole passes through the body unmetabolized after administration, the aim of this study was toExpand
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Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies
Progesterone plays an important role in the female reproductive system. However, there is also evidence that gynecologic disorders/diseases such as uterine fibroids and endometriosis areExpand
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In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, alpha-chlorohydrin and 1-chloro-3-hydroxypropanone.
  • W. Bone, T. Cooper
  • Biology, Medicine
  • International journal of andrology
  • 1 October 2000
Chlorinated antifertility compounds are known to inhibit glycolysis of spermatozoa as they reside in the epididymis but new compounds need to be evaluated that retain antifertility action but do notExpand
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The effect of (R,S)-ornidazole on the fertility of male mice and the excretion and metabolism of 36Cl-(R,S)-ornidazole and 36Cl-(R,S)-alpha-chlorohydrin in male mice and rats.
(R,S)-Ornidazole, an effective antifertility agent for male rats at 400 mg/kg/day, was ineffective at this dose in male mice and at 1000 mg/kg/day caused neural effects. The compound was not excretedExpand
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Lack of antifertility properties of novel halogenated glycolytic inhibitors and the urinary excretion and metabolism of 1,6-dichloro-1,6-dideoxy-D-fructofuranose in the male rat.
The antifertility action of (R,S)-alpha-chlorohydrin administered orally to male rats was compared with that of several novel chlorinated compounds known to inhibit glycolysis and the kinematics ofExpand
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Derivatives of 17-hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-benzylidene, process for their preparation and their use for treating diseases
Derivatives of 17-hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-benzylidene of the general formula (I) ** ** Formula wherein Y represents -CR 1> = CHR2 group or a -CR1> = NR3, in each case isExpand