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Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week, placebo-controlled studies.
TLDR
Paliperidone ER given once daily for 6 weeks appears to be a safe, well-tolerated, and effective treatment for patients with acute schizophrenia. Expand
Prevalence of multimorbidity in a geographically defined American population: patterns by age, sex, and race/ethnicity.
TLDR
Multimorbidity is common in the general population; it increases steeply with older age, has different patterns in men and women, and varies by race/ethnicity. Expand
A randomized, double-blind comparison of clozapine and high-dose olanzapine in treatment-resistant patients with schizophrenia.
TLDR
Olanzapine, at higher than customary doses, demonstrated similar efficacy to clozapine in treatment-resistant schizophrenia and schizoaffective disorder in this study, however, the small sample size precludes definitively concluding that the 2 treatments are equivalent, at these doses, in Treatment- resistant schizophrenia. Expand
Antipsychotics and the risk of type 2 diabetes mellitus in children and youth.
TLDR
Children and youth prescribed antipsychotics had an increased risk of type 2 diabetes that increased with cumulative dose, and the risk increased significantly with increasing cumulative dose. Expand
Antidepressant discontinuation syndrome.
TLDR
Before antidepressants are prescribed, patient education should include warnings about the potential problems associated with abrupt discontinuation, and a high index of suspicion should be maintained for the emergence of discontinuation symptoms. Expand
KETAMINE FOR TREATMENT‐RESISTANT UNIPOLAR AND BIPOLAR MAJOR DEPRESSION: CRITICAL REVIEW AND IMPLICATIONS FOR CLINICAL PRACTICE
TLDR
This clinical review of ketamines will assess the evidence‐based use of ketamine and initial clinical implications of further development of a potentially novel treatment for rapid reduction of symptoms in depressed patients. Expand
Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001–2007: a population-based study of 585,615 deliveries
TLDR
Depression was the most common mental health diagnosis among deliveries to women with atypical antipsychotic use, followed by bipolar disorder and schizophrenia, and studies are needed to examine the comparative safety and effectiveness of these medications relative to other therapeutic options in pregnancy. Expand
Continuation phase intravenous ketamine in adults with treatment-resistant depression.
TLDR
The continuation-phase administration of ketamine at weekly intervals to patients with treatment-resistant depression who remitted during acute-phase ketamine treatment can extend the duration of depressive symptom remission. Expand
Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder.
TLDR
There appears to be a mood-specific relationship between exercise frequency and polarity such that depression is associated with less exercise and mania with more exercise in individuals with bipolar disorder. Expand
Increasing use of atypical antipsychotics and anticonvulsants during pregnancy
TLDR
To quantify maternal use of atypical antipsychotics, typical antipsychotic, anticonvulsants, and lithium during pregnancy, data are collected on mothers' use of these drugs during pregnancy. Expand
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