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Structural implications derived from the analysis of electron paramagnetic resonance spectra of natural and artificial copper proteins.
TLDR
It is concluded that in artificial copper proteins as well as in the naturally occurring nonblue copper proteins copper is ligated to oxygen and nitrogen but not to sulfur. Expand
The orientational freedom of molecular probes. The orientation factor in intramolecular energy transfer.
TLDR
Average depolarization factors are derived for various orientational distribution functions that demonstrate the effects of various mechanisms for reorientation of the luminophores, and it is shown that in general the static averaging regime does not lend itself to determinations of R. Expand
Sulfheme proteins. I. Optical and magnetic properties of sulfmyoglobin and its derivatives.
TLDR
Evidence is presented that the small amount of impurity in the ferrous sulfmyoglobin preparation is present as oxymyoglobin, and an analysis of optical properties supports the hypothesis of a structure in which the elements of H2S add across a β—β double bond of a pyrrole and thereby disrupt the porphyrin conjugation and form a chlorin type structure. Expand
Spin-state changes in cytochrome P-450cam on binding of specific substrates.
  • R. Tsai, C. Yu, +4 authors H. Beinert
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 August 1970
TLDR
It is concluded that P-450(cam) as isolated is equal to or more than 95% in a low spin form probably having sulfur as one of the axial ligands. Expand
Behavioral indicators of lead neurotoxicity: Results of a clinical field survey
TLDR
It was found that secondary lead smelter workers showed significantly poorer performance scores than the nonexposed, control groups, and significant correlations between zinc protoporphyrin levels and behavioral test scores are considered to be consistent with an etiologic relationship between decrement in performance scores and lead effects on the central nervous system. Expand
Zinc protoporphyrin level in blood determined by a portable hematofluorometer: a screening device for lead poisoning.
TLDR
An inexpensive portable fluorometer has been designed which can be used to determine the concentration of zinc protoporphyrin in a drop of unprocessed blood deposited on a disposable glass slide, and comparisons of ZPP levels obtained with the use of the hematofluorometer with erythrocyte protoprophyrin levels obtained using accepted extraction methods are presented. Expand
Electron paramagnetic resonance study of the high- and low-spin forms of cytochrome P-450 in liver and in liver microsomes from a methylcholanthrene-treated rabbit.
  • J. Peisach, W. Blumberg
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 September 1970
TLDR
It is suggested that microsomal cytochrome P-450 can exist in two interconvertible forms, in which the heme iron can either be high-spin or low-spin, depending upon the nature of the nonporphyrin ligands of the metal. Expand
Observations and interpretation of x-ray absorption edges in iron compounds and proteins.
TLDR
X-ray absorption spectra near the Kalpha edge have been measured in various iron group compounds using the intense synchrotron radiation at the Stanford Synchrotrons Research Project and the intensities are shown to agree with those expected on the basis of one electron transitions of the form Z 1s2dn(L,S) leads to (Z + 1)1s2dnn'l'(L",S). Expand
Iron-bleomycin interactions with oxygen and oxygen analogues. Effects on spectra and drug activity.
TLDR
Fe(II)-bleomycin reversibly forms a complex with either CO or isocyanide, either of which interfere with its oxygen-dependent cleavage of DNA, and is accompanied by drug inactivation unless DNA is present. Expand
ELECTRON PARAMAGNETIC RESONANCE STUDIES OF IRON PORPHIN AND CHLORIN SYSTEMS *
TLDR
The mononuclear iron protoporphyrin, at least in the ferric state, has properties which lend themselves to study by electron paramagnetic resonance (EPR) spectroscopy, and this will be the basis for this paper. Expand
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