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HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
Findings provide new insights into the mechanism of flucloxacillin DILI and have the potential to substantially improve diagnosis of this serious disease. Expand
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
Arterial blood lactate measurement rapidly and accurately identifies patients who will die from paracetamol-induced acute liver failure and could improve the speed and accuracy of selection of appropriate candidates for transplantation. Expand
Acute liver failure.
Induced hypothermia is a promising modality of treatment for refractory cerebral oedema, and living donor and auxiliary liver transplantation are likely to improve survival rates further and reduce the number of patients requiring long-term post-transplant immunosuppression. Expand
Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience.
Improved outcomes in the later era, despite higher level patient dependency and greater use of high-risk grafts, through improved graft/recipient matching is indicated. Expand
Acute-on-chronic liver failure
Recognition of acute-on-chronic liver failure as a clinically and pathophysiologically distinct syndrome with defined diagnostic and prognostic criteria will help to encourage the development of new management pathways and interventions to address the unacceptably high mortality. Expand
Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
Ammonia is an independent risk factor for the development of both HE and ICH, and its combination with ammonia increased specificity and accuracy and improved the prediction of HE. Expand
Lessons from look-back in acute liver failure? A single centre experience of 3300 patients.
The nature and outcome of ALF have transformed over 35 years, with major improvements in survival and a fall in prevalence of cerebral oedema and ICH, likely consequent upon earlier illness recognition, improved ICU care, and use of ELT. Expand
High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial.
Treatment with HVP improves outcome in patients with ALF by increasing liver transplantation-free survival by attributable to attenuation of innate immune activation and amelioration of multi-organ dysfunction. Expand
Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis.
Data support an association between infection/SIRS and not ammonia, in patients with cirrhosis that develop severe HE and the presence or absence of infection or SIRS did not determine survival. Expand
ESPEN guideline on clinical nutrition in liver disease.
This update of evidence-based guidelines (GL) aims to translate current evidence and expert opinion into recommendations for multidisciplinary teams responsible for the optimal nutritional andExpand