• Publications
  • Influence
Growth phase in relation to ketoconazole and miconazole susceptibilities of Candida albicans
  • W. Beggs
  • Medicine, Biology
    Antimicrobial Agents and Chemotherapy
  • 1 March 1984
TLDR
It was concluded that C. albicans undergoes phenotypic changes during the growth cycle that coincidentally confer susceptibility or resistance to the lethal direct membrane damage effect of miconazole.
Synergistic action of amphotericin B and rifampin on Candida albicans.
TLDR
It is concluded that amphotericin B and rifampin are synergistic against various yeasts under widely differing experimental conditions.
Action of fluconazole (UK-49,858) in relation to other systemic antifungal azoles.
Viability studies showed that fluconazole (UK-49,858) was strictly fungistatic in its activity against three strains of Candida species, whether tested against yeasts in stationary or early
Physicochemical cell damage in relation to lethal amphotericin B action
  • W. Beggs
  • Medicine, Biology
    Antimicrobial Agents and Chemotherapy
  • 1 February 1994
TLDR
This relationship together with the observed rapidity of both release and killing action supports the conclusion that the lethal action of amphotericin B is primarily physicochemical in nature.
Inhibition of Dihydrostreptomycin Binding to Mycobacterium smegmatis by Monovalent and Divalent Cation Salts
TLDR
It was concluded that monovalent and divalent cation salt antagonism of DSM action on M. smegmatis involves nonspecific interference with drug uptake.
Mechanisms of synergistic interactions between amphotericin B and flucytosine.
  • W. Beggs
  • Medicine
    The Journal of antimicrobial chemotherapy
  • 1 April 1986
Role of ionic strength in salt antagonism of aminoglycoside action on Escherichia coli and Pseudomonas aeruginosa.
TLDR
In both nutrient broth and Mueller-Hinton broth, protection of E. coli from dihydrostreptomycin or gentamicin action by MgCl2, NaCl, or Na2SO4 was attributed to ionic strength alone, and was independent of the particular salt used.
Broth dilution testing of Candida albicans susceptibility to ketoconazole
TLDR
A detailed investigation of the kinetics of ketoconazole activity in the setting of broth dilution testing of Candida albicans susceptibility found determinations of 50% inhibitory concentrations clearly separated the ketconazole-resistant strains from the susceptible strains.
Combined activity of ketoconazole and sulphamethoxazole against Candida albicans.
  • W. Beggs
  • Medicine
    The Journal of antimicrobial chemotherapy
  • 1 December 1982
Irrelevance of growth phase with respect to the Bay n 7133 and ICI 153,066 susceptibilities of Candida albicans.
TLDR
Lethal potential in relation to growth phase was studied with Bay n 7133 and ICI 153,066, two recently developed oral triazoles, each was strictly fungistatic regardless of phase of growth and was almost identical in effect to ketoconazole.
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