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Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection
Human MX2 is a cell-autonomous, anti-HIV-1 resistance factor whose purposeful mobilization may represent a new therapeutic approach for the treatment of HIV/AIDS.
RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection
Identification of a cis-Acting Replication Element within the Poliovirus Coding Region
The conclusion, that this RNA secondary structure constitutes a novel polioviruscis-acting replication element (CRE), is supported by the demonstration that subgenomic replicons bearing lethal mutations in the native structure can be restored to replication competence by the addition of a second copy of the 61-nt wild-type sequence at another location within the genome.
A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA
The influenza A virus proteome includes a 12th primary translation product that (similarly to PB1-F2) is nonessential for virus viability but whose loss, in particular genetic backgrounds, is detrimental to virus replication.
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
Compromised vaccine efficacy against the highly fit and immune-evasive SARS-CoV-2 Delta variant warrants continued infection control measures in the post-vaccination era.
Cellular immune correlates of protection against symptomatic pandemic influenza
In the absence of crossreactive neutralizing antibodies, CD8+ T cells specific to conserved viral epitopes correlated with crossprotection against symptomatic influenza, which could guide universal influenza vaccine development.
Host and viral determinants of influenza A virus species specificity
- Jason S. Long, Bhakti Mistry, S. Haslam, W. Barclay
- BiologyNature Reviews Microbiology
- 25 October 2018
The host barriers that influenza A viruses of animals, especially birds, must overcome to initiate a pandemic in humans are examined and how, on crossing the species barrier, the virus mutates to establish new interactions with the human host is described.
Infection of Human Airway Epithelium by Human and Avian Strains of Influenza A Virus
The nonciliated cell tropism of recent human H3N2 viruses reflects a preference for the sialic acid linkages displayed on these cell types and suggests a drift in the receptor binding phenotype of the H3 hemagglutinin protein as it evolves in humans away from its avian virus precursor.
Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia.
It is shown that the lungs of patients with COVID-19 contain infected pneumocytes with abnormal morphology and frequent multinucleation, which suggest a potential mechanism for CO VID-19 disease pathogenesis and support the repurposing of Niclosamide for therapy.