• Publications
  • Influence
A novel method for nucleic acid sequence determination.
  • W. Bains, G. Smith
  • Biology, Medicine
  • Journal of theoretical biology
  • 7 December 1988
We describe a novel sequencing methodology which should be readily and completely automated. The method relies on fragmentation of a nucleotide or deoxynucleotide sequence into short fragments, andExpand
  • 311
  • 18
Many chemistries could be used to build living systems.
  • W. Bains
  • Chemistry, Medicine
  • Astrobiology
  • 3 September 2004
It has been widely suggested that life based around carbon, hydrogen, oxygen, and nitrogen is the only plausible biochemistry, and specifically that terrestrial biochemistry of nucleic acids,Expand
  • 116
  • 9
  • PDF
Codon distribution in vertebrate genes may be used to predict gene length.
  • W. Bains
  • Biology, Medicine
  • Journal of molecular biology
  • 5 October 1987
I have analysed the coding regions of 96 eukaryotic genes for their use of iso-coding codons. Specific codons occur more frequently in specific positions in all members of some gene families thanExpand
  • 32
  • 3
Exoplanet Biosignatures: A Framework for Their Assessment
We present a framework in which we advocate using biogeochemical “Exo-Earth System” models to simulate potential biosignatures in spectra or photometry. Expand
  • 56
  • 3
  • PDF
How academics can make (extra) money out of their science
  • W. Bains
  • Economics, Medicine
  • Journal of commercial biotechnology
  • 1 July 2005
This paper analyses how UK academics can make money from their expertise, other than through earning their salary. Using statistics from the success rate and likely remuneration from recent examples,Expand
  • 35
  • 3
Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro.
We examined the expression of alpha-skeletal, alpha-cardiac, and beta- and gamma-cytoskeletal actin genes in a mouse skeletal muscle cell line (C2C12) during differentiation in vitro. UsingExpand
  • 153
  • 2
  • PDF
Differential patterns of transcript accumulation during human myogenesis.
We evaluated the extent to which muscle-specific genes display identical patterns of mRNA accumulation during human myogenesis. Cloned satellite cells isolated from adult human skeletal muscle wereExpand
  • 97
  • 2
  • PDF
HERG binding specificity and binding site structure: evidence from a fragment-based evolutionary computing SAR study.
We describe the application of genetic programming, an evolutionary computing method, to predicting whether small molecules will block the HERG cardiac potassium channel. Models based on a molecularExpand
  • 64
  • 2
Hybridization methods for DNA sequencing.
  • W. Bains
  • Biology, Medicine
  • Genomics
  • 1 October 1991
I have conducted a general analysis of the practicability of using oligonucleotide hybridization to sequence DNA. Any DNA sequence may be sequenced by hybridization with a complete panel ofExpand
  • 41
  • 2
Treating Chronic Fatigue states as a disease of the regulation of energy metabolism.
  • W. Bains
  • Biology, Medicine
  • Medical hypotheses
  • 1 October 2008
Chronic Fatigue Syndrome is a physiological state in which the patient feels high levels of fatigue without an obvious organic cause, which affects around 1 in 400 people in the developed world. AExpand
  • 20
  • 2