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Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance
TLDR
Findings show that C. elegansp53 mediates multiple stress responses in the soma, and mediates apoptosis and meiotic chromosome segregation in the germ line, and cep-1mutants show hypersensitivity to hypoxia-induced lethality and decreased longevity in response to starvation-induced stress. Expand
Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.
TLDR
The results support the hypothesis that the most potent chemotherapeutic mechanism of paclitaxel is kinetic stabilization of spindle microtubule dynamics. Expand
Substoichiometric binding of taxol suppresses microtubule dynamics.
TLDR
The data support the hypothesis that binding of a molecule of taxol to a tubulin subunit in microtubules induces a conformational change in that subunit that strongly reduces its ability to dissociate when the subunit becomes exposed at the microtubule end. Expand
The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
TLDR
It is reported that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation. Expand
Structure-Function Analysis of Core STRIPAK Proteins
TLDR
It is proposed that STRIPAK regulates the balance between MST4 localization at the Golgi and in the cytosol to control Golgi positioning and depletion of CCM3 or striatins affects Golgi polarization in an opposite manner. Expand
Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.
TLDR
It is indicated that taxol differentially modulates microtubule dynamics depending upon the beta-tubulin isotype composition, which is consistent with recent studies correlating taxol resistance in tumor cells with increased levels of beta(III0- and beta(IV)-tubulin expression and suggest that altered cellular expression of beta- Tubulin isotypes can be an important mechanism by which tumor cells develop resistance to taxol. Expand
Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network
TLDR
It is found that phg-1, the C. elegans Gas1 (growth arrest-specific 1) homologue, is activated by CEP-1 and is a negative regulator of cell proliferation in the germline in response to genotoxic stress. Expand
CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization*♦
TLDR
Sequence conservation and binding studies suggest that CCM3 may preferentially heterodimerize with GCKIII proteins through a manner structurally analogous to that employed forCCM3 homodimerization. Expand
Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans.
TLDR
These findings demonstrate that cki-1 activity plays an essential role in embryonic cell cycle arrest, differentiation and morphogenesis, and suggest that it may be required to suppress programmed cell death or engulfment of cell corpses. Expand
AKT-1 Regulates DNA-Damage-Induced Germline Apoptosis in C. elegans
TLDR
Akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and AKT-1 regulates apoptosis but not cell-cycle progression downstream of the HUS-1/MRT-2 branch of the DNA damage checkpoint. Expand
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