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Does heterozygosity estimate inbreeding in real populations?
If inbreeding is the dominant mechanism, then the simulations indicate that consanguineous mating would have to be vastly more common than is predicted for most realistic populations, and if heterosis provides the answer, there need to be many more polymorphisms with major fitness effects and higher levels of linkage disequilibrium than are generally assumed. Expand
The influence of parental relatedness on reproductive success
- W. Amos, J. Worthington Wilmer, +4 authors T. Coulson
- Biology, Medicine
- Proceedings of the Royal Society of London…
- 7 October 2001
Examination of three long–lived vertebrates, the long–finned pilot whale, the grey seal and the wandering albatross reveals significant negative relationships between parental similarity and genetic estimates of reproductive success, uncovering a selective pressure that favours not only inbreeding avoidance, but also the selection of maximally dissimilar mates. Expand
Microsatellite genotyping errors: detection approaches, common sources and consequences for paternal exclusion
A large data set comprising almost 2000 Antarctic fur seals genotyped at nine hypervariable microsatellite loci is used to explore error detection methods, common sources of error and the consequences of errors on paternal exclusion. Expand
Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language.
- Z. Rosser, T. Zerjal, +60 authors M. Jobling
- Geography, Medicine
- American journal of human genetics
- 1 December 2000
These patterns retain a strong signal of expansion from the Near East but also suggest that the demographic history of Europe has been complex and influenced by other major population movements, as well as by linguistic and geographic heterogeneities and the effects of drift. Expand
Automated binning of microsatellite alleles: problems and solutions
This work introduces a method that allows repeat units to be fractionally shorter or longer than their theoretical value, and performs well over a wide range of dinucleotide repeat loci. Expand
Microsatellite markers for the study of cetacean populations
The isolation and characterization of 12 cetacean microsatellites are described and no relationship was found between microsatellite repeat length and proportion of species which gave polymorphic products. Expand
Behavioral, ecological, and molecular genetic analyses of reproductive strategies in the Amazonian dart-poison frog, Dendrobates ventrimaculatus
The effect of ancient population bottlenecks on human phenotypic variation
It is shown that the loss in genetic diversity has been mirrored by a loss in phenotypic variability, and evidence is found for an African origin, placed somewhere in the central/southern part of the continent, which harbours the highest intra-population diversity in phenotypesic measurements. Expand
Genetic susceptibility to tuberculosis in Africans: a genome-wide scan.
- R. Bellamy, N. Beyers, +14 authors A. Hill
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 5 July 2000
The results indicate that genome-wide linkage analysis can contribute to the mapping and identification of major genes for multifactorial infectious diseases of humans. Expand
Microsatellite variation in grey seals (Halichoerus grypus) shows evidence of genetic differentiation between two British breeding colonies
Although grey seals are known to range over very large areas outside the breeding season, site fidelity of adults and philopatry of pups for these breeding colonies must be sufficiently common to have effects, through genetic drift, at the sub‐population level. Expand