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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
TLDR
Preclinical studies indicate that when full GLP-1 agonism is augmented with an appropriate degree of glucagon receptor activation, body fat reduction can be substantially enhanced without any overt adverse effects. Expand
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
TLDR
Many of the deleterious effects of high-fat diets, specifically those enriched with palmitic acid, are CNS mediated via PKC-theta activation, resulting in reduced insulin activity. Expand
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
TLDR
Using shRNAs, a dominant-negative mutant, and a pharmacologic inhibitor, mefenamic acid (MFA), it is established that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes the growth of clear cell renal cell carcinoma (ccRCC) and stimulates MAP1LC3A ( LC3A) and MAP1 LC3B (LC3B) autophagy. Expand
High-Density Lipoprotein Maintains Skeletal Muscle Function by Modulating Cellular Respiration in Mice
TLDR
Findings indicate that HDL-raising therapies may preserve muscle mitochondrial function and address key aspects of type 2 diabetes mellitus beyond cardiovascular disease. Expand
Antioxidant potential of specific estrogens on lipid peroxidation.
TLDR
It is shown that equine estrogens (especially equilin) exhibit higher antioxidant potency (as measured by fatty acids and sterols oxidation) when compared to estrone and estradiol-17 beta. Expand
Estimation of cellular DNA content in cell lysates suitable for RNA isolation.
TLDR
A microfluorometric method modified from previous techniques to permit the quantitation of DNA in cell lysates prepared using an acid guanidinium thiocyanate-phenol (AGTP) solution from which RNA can subsequently be isolated. Expand
Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity
TLDR
It is suggested that glucocorticoid signaling specifically in the ARC neurons modulates hepatic insulin responsiveness via NPY and the sympathetic system, which may add to the understanding of the metabolic impact of clinical conditions associated with hypercortisolism. Expand
Mechanisms involved in the protective effect of estradiol-17beta on lipid peroxidation and DNA damage.
TLDR
The studies show that the protection offered by E2 in terms of lipid peroxidation could be due to its ability to inhibit generation of superoxide radical and prevent further chain propagation, and in DNA damage protection, E2 mainly appears to inhibit chain propagation. Expand
Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation.
TLDR
Although all estrogens significantly reduced lipid peroxidation, 4-hydroxyestrone was far more potent than either equilin or 17alpha-dihydroequilin in inhibiting TBARS formation in lipoproteins induced by Cu2+. Expand
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