• Publications
  • Influence
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. TheExpand
Lantibiotics: peptides of diverse structure and function.
The current need for antibiotics with novel target molecules has coincided with advances in technical approaches for the structural and functional analysis of the lantibiotics, which are ribosomallyExpand
Synthesis of Methylphosphonic Acid by Marine Microbes: A Source for Methane in the Aerobic Ocean
It is shown that the marine archaeon Nitrosopumilus maritimus encodes a pathway for methylph phosphonate biosynthesis and that it produces cell-associated methylphosphonate esters, providing a plausible explanation for the methane paradox. Expand
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic
The structures of the two mature haloduracin peptides Halα and Halβ were investigated, indicating that they have similarities as well as some distinct differences compared with other two-component lantibiotics. Expand
Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria
It is shown that a strain of the single-celled, planktonic marine cyanobacterium Prochlorococcus—which conducts a sizable fraction of photosynthesis in the oceans—produces many cyclic, lanthionine-containing peptides (lantipeptides). Expand
Heterologous Expression, Purification, and Characterization of a Highly Active Xylose Reductase from Neurospora crassa
ABSTRACT A xylose reductase (XR) gene was identified from the Neurospora crassa whole-genome sequence, expressed heterologously in Escherichia coli, and purified as a His6-tagged fusion in highExpand
Protein Radicals in Enzyme Catalysis.
Comparison of the properties of prostaglandin H synthase-1 and -2.
The focus of this review is on the structural and biochemical distinctions between PGHS-1 and-2, and how these differences relate to the functional divergence between the two isoforms. Expand
Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights
Identification of a new class of lanthionine synthetases provides insight into the mechanism and evolution of cyclic peptide biosynthesis.