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Correlation between c-erbB-2 amplification and risk of recurrent disease in node-negative breast cancer.
Drawing upon the comprehensive population-based Northern Alberta Breast Cancer Registry containing 704 patients with histologically negative axillary lymph nodes who have been followed for 5-16… Expand
Estrogen receptor in human benign prostatic hyperplasia.
Estrogens have been proposed as a major etiological factor in the pathogenesis of benign prostatic hyperplasia in man. The presence of estrogen receptor in benign prostatic hyperplasia would support… Expand
Distinction between progestin- and glucocorticoid-binding sites in mammary glands. Apparent lack of cytoplasmic progesterone receptors in lactating mammary glands.
The cytosol fraction of the lactating mammary glands of mice does not appear to contain detectable amounts of progesterone receptors. Mixing experiments indicate that the absence of receptors is not… Expand
Differing estrogenic activities for the enantiomers of o, p'-DDT in immature female rats.
- W. A. McBlain, V. Lewin
- Chemistry, Medicine
- Canadian journal of physiology and pharmacology
- 1 August 1976
Female rats (20-21 days) were given single intraperitoneal injections of (+/-)-o,p'-DDT, (--)-o,p'-DDT, or (+)-o,p'-DDT. At 18 h their uteri were excised and the estrogen sensitive parameters,… Expand
The levo enantiomer of o,p'-DDT inhibits the binding of 17 beta-estradiol to the estrogen receptor.
- W. A. McBlain
- Chemistry, Medicine
- Life sciences
- 12 January 1987
It has been discovered previously that the known estrogenic activity of o,p'-DDT resides with the levo enantiomer. Since it has been presumed that this relatively weak estrogenic activity of o,p'-DDT… Expand
Transformation of mammary cytoplasmic glucocorticoid receptor under cell-free conditions.
The transformation of glucocorticoid--receptor complex in the cytosol from lactating mouse mammary tissue was studied by using elevated temperature and KCl as promoters of the transformation… Expand
Inactivation of mammary cytoplasmic glucocorticoid receptors under cell-free conditions.
The conditions for the inactivation of glucocorticoid receptors in the cytosol from lactating mouse mammary glands have been studied in detail. The dexamethasone-binding capacity of cytosol was… Expand
Relationship between concentrations of extractable and matrix-bound nuclear androgen receptor and clinical response to endocrine therapy for prostatic adenocarcinoma.
The relationship between androgen receptor concentrations and clinical response to endocrine therapy for prostatic adenocarcinoma was investigated for 13 stage D patients. Both cytoplasmic and… Expand
An empirical basis for the competition by dexamethasone to progesterone receptors as estimated with the synthetic progestin R5020.
Normal mammary glands of mice contain both progesterone and glucocorticoid receptors and the levels of both these receptors are modulated as a function of development. Measurement of progesterone… Expand
Applicability of nuclear androgen receptor quantification to human prostatic adenocarcinoma.
It has been proposed that concentrations of nuclear androgen receptor may be predictive of tumor hormone dependence in cases of advanced human prostatic cancer. We have investigated the ability of… Expand