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AIMS/HYPOTHESIS FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a(More)
This paper presents AnonymousNet (AnonNet), a system for emergency response in large scale disaster areas, e.g., earthquake and tsunami in Japan (2011) and earthquake in Haiti (2010). Despite the attention the " emergency response " application area has received, we still lack data at the high spatial and temporal resolution needed to save lives, and to(More)
AIMS/HYPOTHESIS Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with common metabolic phenotypes. METHODS The study comprised three stages. We performed medium-depth (8×) whole exome sequencing in(More)
Amniotic epithelial cells (AECs) express Oct4, Nanog and Sox-2, which are necessary for maintaining the undifferentiated state of pluripotent stem cells. AECs additionally express CK19, which is a specific marker of epithelial cells, both in vivo and in vitro. In this research, we investigated the biological characteristics and potential for cell therapy of(More)
The growth of the Cd-hyperaccumulator Solanum nigrum L. and its physiological responses to a short-term (7 d) Cd stress and to exogenous methyl jasmonate (MeJA) were investigated. Compared with the leaves of S. nigrum, the roots were more liable to Cd and showed a significantly decreased dry mass and increased malondialdehyde content. Cd accumulation in the(More)
Storytelling can play a very important role in the success of modern video games. Unfortunately, it can be quite difficult for writers to directly create and integrate story content into games on their own, and they must instead rely upon programmers and others on the development team to implement their stories. This needlessly complicates the game(More)
Particle Swarm Optimisation (PSO) algorithm is a stochastic search technique, which has exhibited good performance across a wide range of applications. However, very often for multimodal problems involving high dimensions, the algorithm tends to suffer from premature convergence. Analysis of the behaviour of the particle swarm model reveals that such(More)
We show how the prevailing majority opinion in a population can be rapidly reversed by a small fraction p of randomly distributed committed agents who consistently proselytize the opposing opinion and are immune to influence. Specifically, we show that when the committed fraction grows beyond a critical value p(c) ≈ 10%, there is a dramatic decrease in the(More)