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n engl j med 375;5 nejm.org August 4, 2016 491 Appendix of our article, available at NEJM.org). In addition to treatment group, histologic findings emerged as an independent variable with regard to both progression-free survival and overall survival. Extent of resection dropped out during the stepwise selection process for both. Consequently, it is unlikely(More)
In locally advanced rectal cancer (LARC) preoperative chemoradiation (CRT) is the standard of care, but the risk of local recurrence is low with good quality total mesorectal excision (TME), although many still develop metastatic disease. Current challenges in treating rectal cancer include the development of effective organ-preserving approaches and the(More)
F-18 FDG PET is increasingly used in the assessment of malignant disease. Normal physiologic activity of FDG can lead to false-positive results. The case of a patient with prior squamous cell carcinoma of the urethra and FDG uptake in the right ovary related to physiological activity during ovulation is presented. Suspicion for physiological ovarian uptake(More)
OBJECTIVE The aims of the study were to (1) evaluate the range of physiological FDG uptake in normal pharyngeal palatine tonsil, and (2) investigate the possibility of establishing a cut-off threshold to distinguish between normal pharyngeal palatine tonsil FDG uptake from occult pharyngeal palatine tonsil primary cancer. METHODS FDG PET CT of 43(More)
OBJECTIVES Peristalsis can lead to confusing FDG PET bowel uptake artefacts and potential for recording inaccurate mean standardised uptake value (SUV) measurements in PET-CT scans. Accordingly, we investigate the influence of different SUV normalisations on FDG PET uptake of the bowel and assess which one(s) have least dependence on body size factors in(More)
BACKGROUND Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histological evidence of tumour. Consequently, a significant proportion of clinicians still practise planned ND.(More)
The assessment of the proliferative activity of breast cancers has been shown to be of prognostic significance [1]. Until recently this has required patients to undergo biopsies for application of histological and immunochemical techniques for measurement of proliferation (such as Ki67 staining, flow cytometry or thymidine labelling index). It is thought(More)
(18)F-FDG PET/CT scanning plays an important role in the management of thoracic malignancy. The authors would like to present FDG PET/CT images of a rare thoracic malignancy, pulmonary blastoma in adulthood. The patient had recurrent metastatic disease of previously resected primary pulmonary blastoma. The foci of recurrent metastases in lung, mediastinum,(More)
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