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We analyze the prospects of a feasible, Brookhaven National Laboratory based, very long baseline neutrino oscillation experiment consisting of a conventional horn produced low energy wideband beam and a detector of 500 kton fiducial mass with modest requirements on event recognition and resolution. Such an experiment is intended primarily to determine CP(More)
The effects of GS-4997 (apoptosis signal-regulating kinase 1 inhibitor) on cardiac repolarization were evaluated using a systematic modeling approach in a first-in-human (FIH) study. High quality, intensive, time-matched 12-lead electrocardiograms (ECGs) were obtained in this placebo-controlled, single and multiple-ascending dose study in healthy subjects.(More)
Yes-associated protein (YAP) is overexpressed and has an oncogenic role in hepatocellular carcinoma (HCC). However, whether membrane protein can serve not only as a tumor marker that reflects YAP function but also as a therapeutic target that stimulates tumorigenesis in HCC remains unknown. Here we report that the membrane protein melanoma cell adhesion(More)
This paper presents preliminary results from an ongoing post-irradiation analysis of materials that have been irradiated at the Brookhaven National Laboratory (BNL) Isotope facility. The effort is part of an experimental study that focuses on how prone to irradiation damage these materials are and thus what is their potential in playing the role of high(More)
Adipose-derived mesenchymal stem cells (ASCs) have been considered to be attractive and readily available adult mesenchymal stem cells (MSCs) and are becoming increasingly popular for use in regenerating cell therapy. However, recent evidence attributed a fibrotic potential to MSCs which differentiated into myofibroblasts with highly increased α-smooth(More)
2. Hamiltonian Dynamics ................... 6 -2.1 Equations of Motion .................. 6 2.2 Symmetry, Integrals, and Cyclic Coordinates ....... 7 2.3 Motion Near a Known Periodic Solution ......... 8 2.4 Change of Independent Variable ............. 9 2.5 The Motion of a Particle in an Accelerator ........ 10 2.6 Floquet’s Theorem .................. 13(More)
Intense beams for muon colliders and neutrino facilities require high-performance target stations of 1-4 MW proton beams. The physics requirements for such a system push the envelope of our current knowledge as to how materials behave under high-power beams for both short and long exposure. The success of an adopted scheme that generates, captures and(More)
Stanford Linear Accelerator Center Stanford Univerrity, Stanjord, Calijornia, 04305 ABSTRACT TABLE I. Tolerancea of Random Imperfections This paper describes the design, construction, and operation of devices used to rapidly measure the mechanical and magnetic properties of some 950 Alternate gradient magnets’ used in the arc system of the Stanford Linear(More)
The energy gain and motion of electrons can quantitatively describe the mechanism of electron multipacting in a long-bunched proton machine. Strong multipacting usually happens around the bunches' tails due to the high energy of electrons when they hit the chamber surface. We investigated several important parameters of electron multipacting, proving that(More)
Resonances in the Presence of the Space Charge Force . . . . . . 3.1 Equations of Motion . . . ; . . . . . . . . . . . . . . . . . 3.2 Amplitude Dependence of the Tune . . . . . . . . . . . . . 3.3 Particle Behavior under Resonance and Space Charge Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . 3.4 Resonance Phase Space Structure with No(More)