W. T. Knoefel

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Abstract Background and aims. This review discusses current concepts regarding the etiology, pathogenesis, diagnosis, and treatment of chronic pancreatitis. Results. Treatment of patients suffering from complications of chronic pancreatitis remains a major challenge. Continuous alcohol consumption, a disease with enormous personal and social impact, is(More)
Neuroendokrine Neoplasien (NEN) des distalen Jejunums und Ileums leiten sich von den serotoninproduzierenden enterochromaffinen Zellen (EC-Zellen) ab. Aufgrund ihrer niedrigen proliferativen Aktivität und ihres infiltrativen Wachstums werden sie klinisch häufig in einem fortgeschrittenen metastasierten Tumorstadium diagnostiziert. Die Biologie dieser(More)
Only few clinical factors predict the prognosis of patients with Ewing tumors. Unfavorable outcome is associated with primary metastatic disease, age > 15 years, tumor volume above 200 ml, and the histological response to chemotherapy. The aim of this study was to elucidate the prevalence and clinical impact of microsatellite instability (MSI) together with(More)
Assuming a benign tumor, soft tissue sarcomas are often treated by inadequate resection. The concept of reexcision in these patients is still under debate. Therefore, it was our goal to evaluate the results of this treatment with particular respect to residual tumor. During a 14-year period, a total of 143 patients were referred to our institution after(More)
Einleitung. Das Internet gewinnt durch zunehmende Verbreitung, vereinfachtem Zugang und rasch wachsendem Informationsangebot auch für medizinische Fragestellungen an Bedeutung. Wir untersuchten anhand des Beispiels “Weichteilsarkom” das Angebot und dessen Informationsgehalt an Internetseiten für Ärzte und Patienten. Methoden. Sechzehn englisch- und(More)
The aim of surgical therapy in Crohn's disease is to improve quality of life. Surgery does not provide cure with radical resection of inflamed bowel. Therefore strictureplasty has become a useful bowel-preserving surgical technique in the treatment of small-bowel stenosis. To preserve functional bowel we extended the indication of this surgical technique to(More)
Drainage and resection are the principles of surgery in chronic pancreatitis. The techniques of duodenum-preserving resection of the head of the pancreas as described by Beger and Frey combine both to different degrees. In a prospective randomized trial both procedures were compared: 74 patients were randomly allocated to either Beger's (n = 38) or Frey's(More)
Except for patients with gastrointestinal stromal tumors (GIST), systemic chemotherapy in patients with liver metastasis of soft-tissue sarcoma (STS) is not effective. Therefore, all patients with resectable liver metastases underwent surgical therapy. We present our experience with this approach during the last 13 years. All patients (n = 45) with liver(More)
The necessary extent of thyroid resection in benign nodular goiter is under debate. The aim of our study was to compare the long-term outcome of different thyroid resection modes with special interest in the incidence of recurrent nodules and the use of oral thyroid hormone medication. We performed a follow-up examination of 109 patients (23 men and 86(More)
Double adenomas (DAs) occur in 2–15 % of primary hyperparathyroidism (pHPT) patients. To date, the existence of this distinct entity remains controversial. The aim of this study was to evaluate the clinical characteristics and anatomic distribution of DAs to identify anatomic patterns and implications for surgical management. We reviewed prospective(More)