W. Shane Grant

Learn More
Vestibular hair cell bundles in the inner ear contain a single kinocilium composed of a 9+2 microtubule structure. Kinocilia play a crucial role in transmitting movement of the overlying mass, otoconial membrane or cupula to the mechanotransducing portion of the hair cell bundle. Little is known regarding the mechanical deformation properties of the(More)
Six utricular hair bundles from a red-eared turtle are modeled using 3-D finite element analysis. The mechanical model includes shear deformable stereocilia, realignment of all forces during force load increments, and tip and lateral link inter-stereocilia connections. Results show that there are two distinct bundle types that can be separated by mechanical(More)
Simplified versions of hair cell bundles are mechanically modeled. The influence of various geometric and material combinations on bundle stiffness, link tensions and deformation shape are examined. Three models are analyzed within this paper: two stereocilia connected by one link, two stereocilia connected by a biologically realistic set of links, and a(More)
Although knowledge of the fine structure of vestibular hair bundles is increasing, the mechanical properties and functional significance of those structures remain unclear. In 2004, Bashtanov and colleagues reported the contribution of different extracellular links to bundle stiffness. We simulated Bashtanov's experimental protocol using a three-dimensional(More)
We have developed a virtual hair cell that simulates hair cell mechanoelectrical transduction in the turtle utricle. This study combines a full three-dimensional hair bundle mechanical model with a gating spring theory. Previous mathematical models represent the hair bundle with a single degree of freedom system which, we have argued, cannot fully explain(More)
We present a robust plane finding algorithm that when combined with plane-based frame-to-frame registration gives accurate real-time pose estimation. Our plane extraction is capable of handling large and sparse datasets such as those generated from spinning multi-laser sensors such as the Velodyne HDL-32E LiDAR. We test our algorithm on frame-to-frame(More)
The virtual hair cell we have proposed utilizes a set of parameters related to its mechanoelectric transduction. In this work, we observed the effect of such channel gating parameters as the gating threshold, critical tension, resting tension, and Ca(2+) concentration. The gating threshold is the difference between the resting and channel opening tension(More)
We describe a method of generating saliency maps that combines symmetry with traditional contrast information. Log Gabor filtering is used to obtain local frequency information that can be used to both calculate local symmetry and edge responses. The symmetry information is combined with center-surround responses from color (either in RGB or LAB),(More)
The use of natural stimuli in neurophysiological studies has led to significant insights into the encoding strategies used by sensory neurons. To investigate these encoding strategies in vestibular receptors and neurons, we have developed a method for calculating the stimuli delivered to a vestibular organ, the utricle, during natural (unrestrained)(More)
A new mathematical model has been developed along with a new parameter estimation routine using surface temperature and heat flux measurements to estimate blood perfusion and thermal resistance in living tissue. Dynamic thermal measurements collected at the surface of the sensor before and after imposing a dynamic thermal cooling event are used with the(More)