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The different participation of the gastrointestinal microflora in the biotransformation of gamma-hexachlorcyclohexane (gamma-HCH), azobenzene and the isolated glucosinolate progoitrin was studied. Marked dehydrochlorination of gamma-HCH to gamma-pentachlorcyclohexene (PCCH) also occurs without participation of the microflora. Azobenzene was reduced in(More)
5-vinyloxazolidine-2-thione (VOT) administered orally to lactating rats was found to be efficiently transferred to the sucklings via the milk. In mothers the exposure to VOT resulted in an increased percentage of neutrophils, a decreased percentage of lymphocytes and increases in the relative weights of liver and thyroid. Suckling rats showed a decreased(More)
The authors describe a method for extracting and determining benzimidazole carbamic acid methyl ester (MBC) in the presence of its metabolites 2-aminobenzimidazole and benzimidazole. The determination is performed thin-layer and paper chromatographically using visual spot comparison. A sensitive biological method is employed for the detection of MBC. The(More)
Groups of male and female rats received 5-vinyloxazolidine-2-thione (VOT) in their drinking water for 13 weeks at concentrations of 0, 10, 25, 50 or 100 mg/l and 0, 2.5 or 5 mg/l respectively. Compared with the controls, there were decreases in food intake and growth of females given VOT-doses of 10 mg/l and higher. Liquid intake was reduced in males and(More)
Microbiological biotransformation as a part of metabolism of foreign compounds in general, has great toxicological consequences. An overview on the most important types of reactions is given. In detail, comparative investigations of the metabolism of gamma-HCH, azobenzene and progoitrin in germfree and conventionalized rats are described and results from(More)
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