W. S. Chelack

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In 25 out of 33 cases the survival response of myeloid progenitor cells from fresh human bone marrows, X-irradiated in vitro in phosphate-buffered saline at 23 degrees C, was characterized by a two-term exponential relationship, with D0 values of 0.42 +/- 0.19 Gy and 1.38 +/- 0.37 Gy, respectively. In the remaining eight cases for which the colony-forming(More)
Human bone marrow progenitor cells, grown on solid agar, developed colonies of the white blood cell series, principally granulocytes, monocytes and macrophages. Following exposure to superoxide radicals, generated photochemically, a fraction of the progenitor cells was inactivated as evidenced by loss of colony formation. The loss in proliferative capacity(More)
X-ray survival of cultured macrophage progenitor cells from mouse bone marrow was represented by a two-component curve, both in the absence and presence of superoxide dismutase. Protection by the enzyme was limited to the radiosensitive fraction, for which a dose modifying factor of 2.8 +/- 0.7 was obtained. Catalase did not protect. Survival of the(More)
1. Hydroperoxide formation in model membranes was measured via the net increase in absorbance at 232 nm after exposure to X-rays or 137Cs gamma rays in the presence and absence of bovine superoxide dismutase and other radical scavengers. 2. Membranes X-irradiated in air to 4200 rad at 210 rad/min exhibited a large increase in absorbance, a major portion of(More)