W Ronald Butler

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Dairy cows suffer from an intense energy deficit at parturition due to the onset of copious milk synthesis and depressed appetite. Despite this deficit, maternal metabolism is almost completely devoted to the support of mammary metabolism. Evidence from rodents suggests that, during periods of nutritional insufficiency, a reduction in plasma leptin serves(More)
Early lactation in dairy cattle is a period of severe negative energy balance (NEB) characterized by reduced blood glucose and insulin concentrations and elevated blood GH concentrations. The liver is refractory to GH during NEB and this uncoupling of the GH-IGF axis results in diminished plasma concentrations of IGF-I. Our objectives were to examine the(More)
In an intial attempt to localize the central components of the neuroendocrine control systems whereby estrogens regulate gonadotropin secretion, the medial basal hypothalamus (MBH) was surgically isolated from the remainder of the brain in 18 female rhesus monkeys using a modified "Halasz knife". The completeness and localization of the resulting "cuts"(More)
Social influences on the sexual maturation of female Djungarian hamsters were investigated in two experiments. In the first experiment females were housed from weaning with an adult male, by themselves, or with a weanling sister. Maturation was accelerated in females housed with males as indicated by younger age at first ovulation, increased rates of(More)
Energy balance controls the expression of the leptin receptor (Lepr) in the ruminant hypothalamus but whether similar regulation occurs in peripheral tissues is unknown. To address this issue, we measured Lepr expression in the liver and adipose tissue of dairy cows during the transition from late pregnancy (LP) to early lactation (EL). This period is(More)
(WSU). Starting with just a handful of students at its launch in 2004, the MPH program has grown to become the dominant responsibility of the CGH. CGH also supports medical student education and curriculum development in prevention and population health, directs the MD/MPH and MD/MBA programs, and offers MPH courses as electives to graduate students in(More)
This study sought to quantify effects of undernutrition on behaviors and to relate these to gonadotropin and prolactin concentrations in the lactating dam. Dams were studied in a 2 x 3 factorial design with litter size and food intake as the two factors. Behavioral data were collected from each dam and her litter on day 9, day 14, and day 19 of lactation,(More)
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