Mapping quantitative trait loci in outbred populations is important because many populations of organisms are noninbred. Unfortunately, information about the genetic architecture of the trait may notâ€¦ (More)

A composite interval gene mapping procedure for complex binary disease traits is proposed in this paper. The binary trait of interest is assumed to be controlled by an underlying liability that isâ€¦ (More)

When pairwise genetic distances are used for phylogenetic reconstruction, it is usually assumed that the genetic distance between two taxa contains information about the time after the two taxaâ€¦ (More)

A new algorithm for finding maximum likelihood (ML) solutions to variance components is introduced. This algorithm first treats random effects as fixed, then expresses the pseudo-fixed effects asâ€¦ (More)

Exact formulas that predict the average inbreeding coefficient and heterozygosity of an F2 generation derived from two segregating populations were developed. When population sizes are sufficientlyâ€¦ (More)

SUMMARY
Patterson and Thompson's idea of 'error contrasts' (or restricted maximum likelihood) (1971) was extended to multiple sets of linear contrasts for variance component estimtion. The errorâ€¦ (More)