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An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with Alzheimer's disease, Down syndrome, and sporadic cerebral amyloid angiopathy. Cloning and sequencing of the two exons that(More)
Hereditary cerebral hemorrhage with amyloidosis in Dutch patients is an autosomal dominant form of vascular amyloidosis restricted to the leptomeninges and cerebral cortex. Clinically the disease is characterized by cerebral hemorrhages leading to an early death. Immunohistochemical studies of five patients revealed that the vascular amyloid deposits(More)
Clinical and neuropathological findings are reported in 63 patients with hereditary cerebral haemorrhage with amyloid angiopathy. Patients had mostly recurrent strokes, and at least 80% of these were haemorrhages. Almost a third of the patients died within a year of their first and only recorded haemorrhage, half of them within two weeks. This angiopathy(More)
Lewit and Sereghy (1975) have expressed some doubts about the existence of the dorsal plica mediana and its relation to the median translucency regularly seen on peridurographic pictures made in the PA projection. The present paper reports the demonstration of the dorsal plica mediana in fresh anatomical preparations under conditions lowering the intradural(More)
This article describes 136 patients with hereditary cerebral haemorrhages; all patients belonged to families (originally) resident in Katwijk (The Netherlands). Cases of hereditary cerebral haemorrhage have also been reported in NW-Iceland, and in the Dutch coastal village of Scheveningen. Katwijk is a Dutch fishing-village, located 20 miles north of(More)
After the first description by Paget (1854) and later on by Mohr (1890) and Schultze (1892), more than 100 years have passed by before it was generally recognized that compression of the median nerve in the carpal tunnel could be related to the majority of cases with nocturnal acroparaesthesiae in the hand and fingers. A short survey is given on 914(More)