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Two pressure measurement techniques (catheter and bulb) were used to decompose the effects of tendon loads on carpal tunnel pressure (CTP). The catheter technique measures true hydrostatic pressure, whereas the bulb technique is a estimate of contact force or pressure on the median nerve. Eight cadaveric wrists were moved through a range of(More)
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to neurological pathologies, such as epilepsy, but the precise mechanisms by which this feedback can occur remain incompletely understood. At(More)
Drosophila peripheral nerves, structured similarly to their mammalian counterparts, comprise a layer of motor and sensory axons wrapped by an inner peripheral glia (analogous to the mammalian Schwann cell) and an outer perineurial glia (analogous to the mammalian perineurium). Growth and proliferation within mammalian peripheral nerves are increased by Ras(More)
Negative feedback processes, which can enable maintenance of neuronal homeostasis, are widely observed in neuronal systems 1-3. For example, neuronal silencing via tetrodotoxin application both in vivo and in vitro increases excitability 4-6. This effect occurs in vitro via both increased sodium currents and decreased potassium currents. However, the(More)
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