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The transition from quiescence to proliferation is a key regulatory step that can be induced by serum stimulation in cultured fibroblasts. The transcription factor Myc is directly induced by serum mitogens and drives a secondary gene expression program that remains largely unknown. Using mRNA profiling, we identify close to 300 Myc-dependent serum response(More)
In the Dialogue for Reverse Engineering Assessments and Methods Conference (DREAM2) BCL6 target identification challenge, we were given a list of 200 genes and tasked to identify which ones are the true targets of BCL6 using an independent panel of gene-expression data. Initial efforts using conventional motif-scanning approaches to find BCL6 binding sites(More)
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