W K Distler

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OBJECTIVE To elucidate changes in gonadotropin secretion pattern in patients with hyperandrogenemic chronic anovulation of various origins. DESIGN AND PARTICIPANTS Hyperandrogenemic patients (n = 32), divided into subgroups according to certain clinical and biochemical criteria, and a control group (n = 9) of regularly cycling women with normal androgen(More)
Normal values of unconjugated, total, and immunoreactive (measured without extraction) plasma estriol (E3) have been determined from radioimmunoassay data obtained in 217 uncomplicated third-trimester pregnancies. Small but significant diurnal variations in unconjugated and total plasma E3 have been observed in a study comprising 12 women who were(More)
The importance of the pacemaker follow-up clinic has markedly increased in the face of the currently available multiprogrammable pacemakers. In contrast to the common standard techniques in assessing pacemaker dysfunctions, Holter monitoring allows the detection of transient pace-maker dysfunctions during a long period of time. Especially computer-aided(More)
The clinical course of AIDS in a child of a HTLV III virus infected drug addicted mother is reported. Aged 7 month the baby died from Pneumocystis carinii pneumonia. The clinical course prior to the final lethal infection was remarkably uneventful. Immunological controls revealed strikingly high immunoglobulin values, whereas only minor changes of cellular(More)
Beta-endorphin (beta-EP) concentrations in hypophyseal portal blood are related to the menstrual cycle in primates. In women, changes in peripheral plasma beta-EP-concentrations were detected throughout the menstrual cycle. A similar circadian rhythm of beta-EP and ACTH was observed in males, suggesting a common mechanism of secretion at the pituitary(More)
In 50 pregnancies morphometric parameters of the placenta and the serum estriol values in the third trimester were correlated. The results show that there is no correlation between the placental parameters as determined by a semi-automatic method and the estriol values in maternal serum in late pregnancy. The placental parameters probably do not reflect the(More)
This case report describes for the first time a manifestation of thrombotic thrombocytopenic purpura (TTP, Moschcowitz's disease) during pregnancy. The characteristic neurologic symptoms of TTP were missing, while the typical clinical signs of the HELLP syndrome could be observed. Furthermore the biochemical proof of TTP was obtained by tracing ultra-large(More)