W. Jeffrey Fessel

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BACKGROUND The HIV-1 nucleoside RT inhibitor (NRTI)-resistance mutation, K65R confers intermediate to high-level resistance to the NRTIs abacavir, didanosine, emtricitabine, lamivudine, and tenofovir; and low-level resistance to stavudine. Several lines of evidence suggest that K65R is more common in HIV-1 subtype C than subtype B viruses. METHODS AND(More)
1945, twenty patients with acute rheumatic fever have been studied and treated at the Permanente Foundation Hospital. All cases occurred among workers in the Richmond shipyards. The diagnostic criteria used were those set forth recently by Jones. 1 The major criteria for diagnosis were: 1) Active carditis, as evi-denced by the development of(More)
OBJECTIVES To determine whether pan-protease inhibitor (PI)-resistant virus populations are composed predominantly of viruses with resistance to all PIs or of diverse virus populations with resistance to different subsets of PIs. METHODS We performed deep sequencing of plasma virus samples from nine patients with high-level genotypic and/or phenotypic(More)
BACKGROUND Nonnucleoside reverse transcriptase inhibitor (NNRTI)-associated transmitted drug resistance (TDR) is the most common type of TDR. Few data guide the selection of antiretroviral therapy (ART) for patients with such resistance. METHODS We reviewed treatment outcomes in a cohort of HIV-1-infected patients with isolated NNRTI TDR who initiated ART(More)
BACKGROUND To identify the determinants of successful antiretroviral (ARV) therapy, researchers study the virological responses to treatment-change episodes (TCEs) accompanied by baseline plasma HIV-1 RNA levels, CD4+ T lymphocyte counts, and genotypic resistance data. Such studies, however, often differ in their inclusion and virological response criteria(More)
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